Moderate influenza vaccine effectiveness against A(H1N1)pdm09 virus, and low effectiveness against A(H3N2) subtype, 2018/19 season in Italy

被引：19

作者：

Bellino, Stefania ^{[1
]}

Bella, Antonino ^{[1
]}

Puzelli, Simona ^{[1
]}

Di Martino, Angela ^{[1
]}

Facchini, Marzia ^{[1
]}

Punzo, Ornella ^{[1
]}

Pezzotti, Patrizio ^{[1
]}

Castrucci, Maria Rita ^{[1
]}

Di Mario, Giuseppina ^{[2
]}

Calzoletti, Laura ^{[2
]}

Fabiani, Concetta ^{[2
]}

Chironna, Maria ^{[3
]}

Germinario, Cinzia ^{[4
]}

Tramuto, Fabio ^{[5
]}

Di Carlo, Vittorio

Affanni, Paola ^{[6
]}

Pascucci, Maria Grazia ^{[7
]}

D'Agaro, Pierlanfranco ^{[8
]}

Gallo, Tolinda ^{[9
]}

Pagani, Elisabetta ^{[10
]}

Natter, Bernhard ^{[11
]}

Camilloni, Barbara ^{[12
]}

Tosti, Anna ^{[13
]}

Pariani, Elena ^{[14
]}

Senatore, Sabrina ^{[15
]}

Serra, Caterina ^{[16
]}

Tanchis, Pierina Rita ^{[17
]}

Ghisetti, Valeria ^{[18
]}

Tiberti, Donatella ^{[19
]}

Romano, Lucio ^{[20
]}

Volpe, Enrico ^{[21
]}

Giannecchini, Simone ^{[22
]}

机构：

[1] Natl Inst Hlth, Ist Super Sanita, Dept Infect Dis, Rome, Italy

[2] ISS, Dept Infect Dis, Rome, Italy

[3] Hosp Univ Bari, Mol Epidemiol & Publ Hlth Lab, Bari, Italy

[4] Univ Bari, Dept Biomed Sci & Human Oncol, Hyg Sect, Bari, Italy

[5] Univ Palermo, Dept Hlth Promot Sci & Mother Child Care G DAless, Palermo, Italy

[6] Univ Parma, Dept Med & Surg, Parma, Italy

[7] Reg Hlth Author, Bologna, Italy

[8] Univ Trieste, Dept Med Surg & Hlth Sci, Trieste, Italy

[9] Integrated Hlth Unit, Prevent Infect Dis Vaccinat & Travel Med, Udine, Italy

[10] Alto Adige Hlth Unit, Microbiol & Virol Lab, Bolzano, Italy

[11] Prevent Hlth Promot & Publ Hlth Off, Bolzano, Autonomous Prov, Italy

[12] Univ Perugia, Dept Med, Microbiol Unit, Perugia, Italy

[13] Reg Directorate Hlth & Welf, Perugia, Italy

[14] Univ Milan, Dept Biomed Sci Hlth, Milan, Italy

[15] Gen Welf Directorate, Milan, Italy

[16] Univ Sassari, Dept Biomed Sci, Sassari, Italy

[17] Hyg & Hlth Promot, Cagliari, Italy

[18] Amedeo Savoia Hosp, Lab Microbiol & Virol, Turin, Italy

[19] Reg Reference Serv Epidemiol Prevent Surveillance, Alessandria, Italy

[20] Univ Cattolica Sacro Cuore, A Gemelli Univ Polyclin Fdn, Dept Lab Sci & Infect Dis, Rome, Italy

[21] Reg Directorate Integrated Hlth & Social Serv, Rome, Italy

[22] Univ Florence, Dept Expt & Clin Med, Florence, Italy

来源：

EXPERT REVIEW OF VACCINES | 2019年 / 18卷 / 11期

关键词：

Influenza vaccine effectiveness; test-negative case-control study; national influenza surveillance network; Italy; MORTALITY; EFFICACY;

D O I：

10.1080/14760584.2019.1688151

中图分类号：

R392 [医学免疫学]; Q939.91 [免疫学];

学科分类号：

100102 ;

摘要：

Background: Influenza vaccines are updated every year to match the vaccine strains with currently circulating viruses; consequently influenza vaccine effectiveness (IVE) has to be assessed annually. Research design and methods: A test-negative case-control study was conducted within the context of the Italian sentinel influenza surveillance network to estimate IVE by age group, virus subtype, and vaccine brand in medically attended laboratory-confirmed influenza. Results: In Italy, the 2018/19 influenza season was characterized by the co-circulation of influenza A(H1N1)pdm09 and A(H3N2) viruses. The adjusted IVE estimate in preventing influenza was moderate (44.8%, 95% CI: 18.8 to 62.5) against A(H1N1)pdm09, whereas there was no evidence of effectiveness (1.8%, 95% CI: -37.8 to 30.1) in persons affected by A(H3N2). IVE against A(H1N1)pdm09 decreased with age ranging from 65.7% to 13.1% among children/adolescents and elderly, respectively; moreover results suggest that Vaxigrip Tetra (R) was more effective against A(H1N1)pdm09 compared to Fluarix Tetra (R) [62.5% (95% CI: 34.3 to 78.6) vs 24.5% (95% CI: -40.6 to 59.6)]. Low effectiveness (35.2%, 95% CI: -50.8 to 72.1) against A(H3N2) was detected only in the elderly immunized with Fluad (R). Conclusions: Findings suggest that influenza vaccines were low to moderately effective, probably due to a mismatch between circulating and vaccine strains.

引用

页码：1201 / 1209

页数：9

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