Moderate influenza vaccine effectiveness against A(H1N1)pdm09 virus, and low effectiveness against A(H3N2) subtype, 2018/19 season in Italy

被引：21

作者：

Bellino, Stefania ^{[1
]}

Bella, Antonino ^{[1
]}

Puzelli, Simona ^{[1
]}

Di Martino, Angela ^{[1
]}

Facchini, Marzia ^{[1
]}

Punzo, Ornella ^{[1
]}

Pezzotti, Patrizio ^{[1
]}

Castrucci, Maria Rita ^{[1
]}

Di Mario, Giuseppina ^{[2
]}

Calzoletti, Laura ^{[2
]}

Fabiani, Concetta ^{[2
]}

Chironna, Maria ^{[3
]}

Germinario, Cinzia ^{[4
]}

Tramuto, Fabio ^{[5
]}

Di Carlo, Vittorio

Affanni, Paola ^{[6
]}

Pascucci, Maria Grazia ^{[7
]}

D'Agaro, Pierlanfranco ^{[8
]}

Gallo, Tolinda ^{[9
]}

Pagani, Elisabetta ^{[10
]}

Natter, Bernhard ^{[11
]}

Camilloni, Barbara ^{[12
]}

Tosti, Anna ^{[13
]}

Pariani, Elena ^{[14
]}

Senatore, Sabrina ^{[15
]}

Serra, Caterina ^{[16
]}

Tanchis, Pierina Rita ^{[17
]}

Ghisetti, Valeria ^{[18
]}

Tiberti, Donatella ^{[19
]}

Romano, Lucio ^{[20
]}

Volpe, Enrico ^{[21
]}

Giannecchini, Simone ^{[22
]}

机构：

[1] Natl Inst Hlth, Ist Super Sanita, Dept Infect Dis, Rome, Italy

[2] ISS, Dept Infect Dis, Rome, Italy

[3] Hosp Univ Bari, Mol Epidemiol & Publ Hlth Lab, Bari, Italy

[4] Univ Bari, Dept Biomed Sci & Human Oncol, Hyg Sect, Bari, Italy

[5] Univ Palermo, Dept Hlth Promot Sci & Mother Child Care G DAless, Palermo, Italy

[6] Univ Parma, Dept Med & Surg, Parma, Italy

[7] Reg Hlth Author, Bologna, Italy

[8] Univ Trieste, Dept Med Surg & Hlth Sci, Trieste, Italy

[9] Integrated Hlth Unit, Prevent Infect Dis Vaccinat & Travel Med, Udine, Italy

[10] Alto Adige Hlth Unit, Microbiol & Virol Lab, Bolzano, Italy

[11] Prevent Hlth Promot & Publ Hlth Off, Bolzano, Autonomous Prov, Italy

[12] Univ Perugia, Dept Med, Microbiol Unit, Perugia, Italy

[13] Reg Directorate Hlth & Welf, Perugia, Italy

[14] Univ Milan, Dept Biomed Sci Hlth, Milan, Italy

[15] Gen Welf Directorate, Milan, Italy

[16] Univ Sassari, Dept Biomed Sci, Sassari, Italy

[17] Hyg & Hlth Promot, Cagliari, Italy

[18] Amedeo Savoia Hosp, Lab Microbiol & Virol, Turin, Italy

[19] Reg Reference Serv Epidemiol Prevent Surveillance, Alessandria, Italy

[20] Univ Cattolica Sacro Cuore, A Gemelli Univ Polyclin Fdn, Dept Lab Sci & Infect Dis, Rome, Italy

[21] Reg Directorate Integrated Hlth & Social Serv, Rome, Italy

[22] Univ Florence, Dept Expt & Clin Med, Florence, Italy

来源：

EXPERT REVIEW OF VACCINES | 2019年 / 18卷 / 11期

关键词：

Influenza vaccine effectiveness; test-negative case-control study; national influenza surveillance network; Italy; MORTALITY; EFFICACY;

D O I：

10.1080/14760584.2019.1688151

中图分类号：

R392 [医学免疫学]; Q939.91 [免疫学];

学科分类号：

100102 ;

摘要：

Background: Influenza vaccines are updated every year to match the vaccine strains with currently circulating viruses; consequently influenza vaccine effectiveness (IVE) has to be assessed annually. Research design and methods: A test-negative case-control study was conducted within the context of the Italian sentinel influenza surveillance network to estimate IVE by age group, virus subtype, and vaccine brand in medically attended laboratory-confirmed influenza. Results: In Italy, the 2018/19 influenza season was characterized by the co-circulation of influenza A(H1N1)pdm09 and A(H3N2) viruses. The adjusted IVE estimate in preventing influenza was moderate (44.8%, 95% CI: 18.8 to 62.5) against A(H1N1)pdm09, whereas there was no evidence of effectiveness (1.8%, 95% CI: -37.8 to 30.1) in persons affected by A(H3N2). IVE against A(H1N1)pdm09 decreased with age ranging from 65.7% to 13.1% among children/adolescents and elderly, respectively; moreover results suggest that Vaxigrip Tetra (R) was more effective against A(H1N1)pdm09 compared to Fluarix Tetra (R) [62.5% (95% CI: 34.3 to 78.6) vs 24.5% (95% CI: -40.6 to 59.6)]. Low effectiveness (35.2%, 95% CI: -50.8 to 72.1) against A(H3N2) was detected only in the elderly immunized with Fluad (R). Conclusions: Findings suggest that influenza vaccines were low to moderately effective, probably due to a mismatch between circulating and vaccine strains.

引用

页码：1201 / 1209

页数：9

共 31 条

[1] JS']JSH Guidelines for the Management of Hepatitis B Virus Infection [J].

Asahina, Yasuhiro ;

Hayashi, Norio ;

Hiramatsu, Naoki ;

Izumi, Namiki ;

Koike, Kazuhiko ;

Kumada, Hiromitsu ;

Kurosaki, Masayuki ;

Oketani, Makoto ;

Suzuki, Fumitaka ;

Takikawa, Hajime ;

Tanaka, Atsushi ;

Tanaka, Eiji ;

Tanaka, Yasuhito ;

Tsubouchi, Hirohito ;

Yotsuyanagi, Hiroshi .

HEPATOLOGY RESEARCH, 2014, 44 :1-58

[2] Recalling the Future: Immunological Memory Toward Unpredictable Influenza Viruses [J].

Auladell, Maria ;

Jia, Xiaoxiao ;

Hensen, Luca ;

Chua, Brandon ;

Fox, Annette ;

Nguyen, Thi H. O. ;

Doherty, Peter C. ;

Kedzierska, Katherine .

FRONTIERS IN IMMUNOLOGY, 2019, 10

[3]

Australian Government, 2018, INFL SEAS AUSTR SUMM

[4] Variable influenza vaccine effectiveness by subtype: a systematic review and meta-analysis of test-negative design studies [J].

Belongia, Edward A. ;

Simpson, Melissa D. ;

King, Jennifer P. ;

Sundaram, Maria E. ;

Kelley, Nicholas S. ;

Osterholm, Michael T. ;

McLean, Huong Q. .

LANCET INFECTIOUS DISEASES, 2016, 16 (08) :942-951

[5] Antibody responses to intradermal or intramuscular MF59-adjuvanted influenza vaccines as evaluated in elderly institutionalized volunteers during a season of partial mismatching between vaccine and circulating A(H3N2) strains [J].

Camilloni, Barbara ;

Basileo, Michela ;

Di Martino, Angela ;

Donatelli, Isabella ;

Iorio, Anna Maria .

IMMUNITY & AGEING, 2014, 11

[6] Adjuvanted influenza vaccine for the Italian elderly in the 2018/19 season: an updated health technology assessment [J].

de Waure, Chiara ;

Boccalini, Sara ;

Bonanni, Paolo ;

Amicizia, Daniela ;

Poscia, Andrea ;

Bechini, Angela ;

Barbieri, Marco ;

Capri, Stefano ;

Specchia, Maria Lucia ;

Di Pietro, Maria Luisa ;

Arata, Lucia ;

Cacciatore, Pasquale ;

Panatto, Doanatella ;

Gasparini, Roberto .

EUROPEAN JOURNAL OF PUBLIC HEALTH, 2019, 29 (05) :900-905

[7] Interim Estimates of 2018-19 Seasonal Influenza Vaccine Effectiveness - United States, February 2019 [J].

Doyle, Joshua D. ;

Chung, Jessie R. ;

Kim, Sara S. ;

Gaglani, Manjusha ;

Raiyani, Chandni ;

Zimmerman, Richard K. ;

Nowalk, Mary Patricia ;

Jackson, Michael L. ;

Jackson, Lisa A. ;

Monto, Arnold S. ;

Martin, Emily T. ;

Belongia, Edward A. ;

McLean, Huong Q. ;

Foust, Angie ;

Sessions, Wendy ;

Berman, LaShondra ;

Garten, Rebecca J. ;

Barnes, John R. ;

Wentworth, David E. ;

Fry, Alicia M. ;

Patel, Manish M. ;

Flannery, Brendan .

MMWR-MORBIDITY AND MORTALITY WEEKLY REPORT, 2019, 68 (06) :135-139

[8]

ECDC, 2019, INFL VIR CHAR SUMM E

[9]

European Centre for Disease Prevention and Control, 2017, EXP OP NEUR INH PREV

[10]

European Centre for Disease Prevention and Control, 2009, PROT CAS CONTR STUD

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