Investigating the effect of Fenofibrate on biomarkers of vascular inflammation in L-NAME induced hypertensive rats

被引：0
作者：
Berzinji, Begard [1 ]
Dizaye, Kawa [1 ]
机构：
[1] Hawler Med Univ, Erbil, Iraq
来源：
PHARMACIA | 2022年 / 69卷 / 02期
关键词：
Fenofibrate; hypertension; inflammatory biomarkers; TYPE-2; DIABETES-MELLITUS; NITRIC-OXIDE SYNTHASE; PHOSPHOLIPASE-A2; LP-PLA2; ENDOTHELIAL DYSFUNCTION; CARDIOVASCULAR-DISEASE; CD40/CD40; LIGAND; KIDNEY-FUNCTION; RISK; MARKERS; TRIGLYCERIDES;
D O I：
10.3897/pharmacia.69.e81078
中图分类号：
R9 [药学];
学科分类号：
1007 ;
摘要：
This study aims to evaluate the impact of fenofibrate on the levels of (IL-6, hsCRP, Lp-PLA2, sCD40L, and cystatin C) in hypertensive rats. Twenty-four rats were divided into two groups each of twelve. The first group served as the normotensive group, while the second group was regarded as the hypertensive group. Each group was further divided into two subgroups (control and treated). The control subgroups only received a placebo and the treated subgroups were given fenofibrate 30 mg/kg daily orally by gastric gavage for 4 weeks. The level of hsCRP, IL6, and Lp-PLA2 significantly increased, but sCD40L and cystatin C levels were not changed in hypertensive rats. Fenofibrate has significantly reduced the levels of hsCRP and Lp-LPA2 in hypertensive rats while IL6 and sCD40s have not been changed in both groups. In conclusion, Fenofibrate has revealed a pleiotropic anti-inflammatory effect by reducing the level of hsCRP and Lp-LPA2 in hypertensive rats.
引用
收藏
页码：459 / 465
页数：7
相关论文
共 50 条
[31]   Contribution of endothelin to the acute pressor response of L-NAME in stroke-prone spontaneously hypertensive rats [J].
Fink, J ;
Fan, NYT ;
Rosenfeld, L ;
Stier, CT .
JOURNAL OF CARDIOVASCULAR PHARMACOLOGY, 1998, 31 (04) :618-622
[32]   Blood pressure lowering effect of an olive leaf extract (Olea europaea) in L-NAME induced hypertension in rats [J].
Khayyal, MT ;
El-Ghazaly, MA ;
Abdallah, DM ;
Nassar, NN ;
Okpanyi, SN ;
Kreuter, MH .
ARZNEIMITTEL-FORSCHUNG-DRUG RESEARCH, 2002, 52 (11) :797-802
[33]   Electrical stimulation of the carotid sinus lowers arterial pressure and improves heart rate variability in l-NAME hypertensive conscious rats [J].
Domingos-Souza, Gean ;
Santos-Almeidal, Fernanda Machado ;
Meschiar, Cesar Arruda ;
Ferreira, Nathanne S. ;
Pereira, Camila A. ;
Martinez, Diana ;
Martins Dias, Daniel Penteado ;
Virgilio Silva, Luiz Eduardo ;
Castania, Jaci Airton ;
Tostes, Rita C. ;
Fazan Jr, Rubens .
HYPERTENSION RESEARCH, 2020, 43 (10) :1057-1067
[34]   Nitric oxide inhibitor L-NAME suppresses mechanically induced bone formation in rats [J].
Turner, CH ;
Takano, Y ;
Owan, I ;
Murrell, GAC .
AMERICAN JOURNAL OF PHYSIOLOGY-ENDOCRINOLOGY AND METABOLISM, 1996, 270 (04) :E634-E639
[35]   Peristrophe roxburghiana leaf extracts exhibited anti-hypertensive and anti-lipidemic properties in L-NAME hypertensive rats [J].
Aluko, Esther Oluwasola ;
Adejumobi, Olumuyiwa Abiola ;
Fasanmade, Adesoji Adedipe .
LIFE SCIENCES, 2019, 234
[36]   Effect of lisinopril on rat liver tissues in L-NAME induced hypertension model [J].
Alpaslan Gokcimen ;
Ahmet Kocak ;
Serkan Kilbas ;
Dilek Bayram ;
Aynur Kilbas ;
Abdullah Cim ;
Cem Kockar ;
Suleyman Kutluhan .
Molecular and Cellular Biochemistry, 2007, 296 :159-164
[37]   Effect of lisinopril on rat liver tissues in L-NAME induced hypertension model [J].
Gokcimen, Alpaslan ;
Kocak, Ahmet ;
Kilbas, Serkan ;
Bayram, Dilek ;
Kilbas, Aynur ;
Cim, Abdullah ;
Kockar, Cem ;
Kutluhan, Suleyman .
MOLECULAR AND CELLULAR BIOCHEMISTRY, 2007, 296 (1-2) :159-164
[38]   Effects of quercetin on heart nitric oxide metabolism in L-NAME treated rats [J].
Calabro, Valeria ;
Litterio, Maria C. ;
Fraga, Cesar G. ;
Galleano, Monica ;
Piotrkowski, Barbara .
ARCHIVES OF BIOCHEMISTRY AND BIOPHYSICS, 2018, 647 :47-53
[39]   Spironolactone suppresses inflammation and prevents L-NAME-induced renal injury in rats [J].
Ikeda, Hirofumi ;
Tsuruya, Kazuhiko ;
Toyonaga, Jiro ;
Masutani, Kohsuke ;
Hayashida, Hideko ;
Hirakata, Hideki ;
Iida, Mitsuo .
KIDNEY INTERNATIONAL, 2009, 75 (02) :147-155
[40]   MULTIPLEXED IMMUNOASSAYS FOR SIMULTANEOUS QUANTIFICATION OF CARDIOVASCULAR BIOMARKERS IN THE MODEL OF HG-NITRO-L-ARGININE METHYLESTER (L-NAME) HYPERTENSIVE RAT [J].
Adamcova, M. ;
Ruzickova, S. ;
Simko, F. .
JOURNAL OF PHYSIOLOGY AND PHARMACOLOGY, 2013, 64 (02) :211-217
12345