Investigating the effect of Fenofibrate on biomarkers of vascular inflammation in L-NAME induced hypertensive rats

被引:0
|
作者
Berzinji, Begard [1 ]
Dizaye, Kawa [1 ]
机构
[1] Hawler Med Univ, Erbil, Iraq
关键词
Fenofibrate; hypertension; inflammatory biomarkers; TYPE-2; DIABETES-MELLITUS; NITRIC-OXIDE SYNTHASE; PHOSPHOLIPASE-A2; LP-PLA2; ENDOTHELIAL DYSFUNCTION; CARDIOVASCULAR-DISEASE; CD40/CD40; LIGAND; KIDNEY-FUNCTION; RISK; MARKERS; TRIGLYCERIDES;
D O I
10.3897/pharmacia.69.e81078
中图分类号
R9 [药学];
学科分类号
1007 ;
摘要
This study aims to evaluate the impact of fenofibrate on the levels of (IL-6, hsCRP, Lp-PLA2, sCD40L, and cystatin C) in hypertensive rats. Twenty-four rats were divided into two groups each of twelve. The first group served as the normotensive group, while the second group was regarded as the hypertensive group. Each group was further divided into two subgroups (control and treated). The control subgroups only received a placebo and the treated subgroups were given fenofibrate 30 mg/kg daily orally by gastric gavage for 4 weeks. The level of hsCRP, IL6, and Lp-PLA2 significantly increased, but sCD40L and cystatin C levels were not changed in hypertensive rats. Fenofibrate has significantly reduced the levels of hsCRP and Lp-LPA2 in hypertensive rats while IL6 and sCD40s have not been changed in both groups. In conclusion, Fenofibrate has revealed a pleiotropic anti-inflammatory effect by reducing the level of hsCRP and Lp-LPA2 in hypertensive rats.
引用
收藏
页码:459 / 465
页数:7
相关论文
共 50 条
  • [1] Effect of chrysin endothelial vasodilation on L-NAME induced hypertensive rats
    Ramanathan, Veerappan
    Anandu, Dominic Amalraj Arul
    Malarvili, T.
    INDIAN JOURNAL OF BIOCHEMISTRY & BIOPHYSICS, 2020, 57 (05): : 572 - 577
  • [2] EFFECT OF LEVOSIMENDAN, A CALCIUM SENSITIZER, ON RENAL HEMODYNAMICS IN L-NAME INDUCED HYPERTENSIVE RATS
    Abdelrahman, A.
    Suleimani, Y.
    Ashique, M.
    Manoj, P.
    Saidi, H. A.
    Ali, B.
    JOURNAL OF HYPERTENSION, 2019, 37 : E101 - E101
  • [3] β-sitosterol on heart rate variability in L-NAME induced hypertensive rats
    Patel, Sanakousar
    Aithala, Manjunatha
    Patil, Sumangala
    Das, Kusal K.
    JOURNAL OF KRISHNA INSTITUTE OF MEDICAL SCIENCES UNIVERSITY, 2023, 12 (01) : 97 - 106
  • [4] Sympathetic activity is not increased in L-NAME hypertensive rats
    dos Santos, Fernanda Machado
    Martins Dias, Daniel Penteado
    Aguiar da Silva, Carlos Alberto
    Fazan, Rubens, Jr.
    Salgado, Helio Cesar
    AMERICAN JOURNAL OF PHYSIOLOGY-REGULATORY INTEGRATIVE AND COMPARATIVE PHYSIOLOGY, 2010, 298 (01) : R89 - R95
  • [5] Beneficial Effects of Different Flavonoids on Vascular and Renal Function in L-NAME Hypertensive Rats
    Dolores Paredes, M.
    Romecin, Paola
    Atucha, Noemi M.
    O'Valle, Francisco
    Castillo, Julian
    Clara Ortiz, M.
    Garcia-Estan, Joaquin
    NUTRIENTS, 2018, 10 (04)
  • [6] Effect of pioglitazone on L-NAME induced hypertension in diabetic rats
    Majithiya, JB
    Parmar, AN
    Trivedi, CJ
    Balaraman, R
    VASCULAR PHARMACOLOGY, 2005, 43 (04) : 260 - 266
  • [7] EFFECT OF LOW DOSE L-NAME PRETREATMENT ON NITRIC OXIDE/REACTIVE OXYGEN SPECIES BALANCE AND VASOACTIVITY IN L-NAME/SALT-INDUCED HYPERTENSIVE RATS
    Vrankova, S.
    Zemancikova, A.
    Torok, J.
    Pechanova, O.
    JOURNAL OF PHYSIOLOGY AND PHARMACOLOGY, 2019, 70 (04): : 535 - 544
  • [8] ANTIHYPERTENSIVE AND ANTIHYPERLIPIDEMIC ACTIVITIES OF THYMOQUINONE IN L-NAME HYPERTENSIVE RATS
    Azzubaidi, Marwan S.
    Noor, Noriah M.
    Mizher, Hussam A.
    JOURNAL OF HYPERTENSION, 2015, 33 : E7 - E8
  • [9] Preglomerular sudanophilia in L-NAME hypertensive rats - Involvement of endothelin
    Bouriquet, N
    Dupont, M
    Herizi, A
    Mimran, A
    Casellas, D
    HYPERTENSION, 1996, 27 (03) : 382 - 391
  • [10] Effect of Oxytocin on L-NAME Induced Hypertension and Chronic Stress in Rats
    Yildirim, Alper
    Vatan, Merve
    Dursun, Esra
    Aykan, Merve
    Yurtcan, Hilal
    Arpaci, Dilara
    Buzcu, Hulya
    Cumbul, Alev
    Uslu, Unal
    ACTA PHYSIOLOGICA, 2015, 215 : 23 - 23