Aspiration occurence during chemoradiation for head and neck cancer

被引：0
作者：
Nguyen, Nam P.
Smith, Herbert J.
Dutta, Suresh
Alfieri, Alan
North, Debra
Nguyen, Phuc D.
Lee, Howard
Martinez, Tomas
Lemanski, Claire
Ludin, Adir
Nguyen, Ly M.
Sallah, Sabah
机构：
[1] Univ Arizona, Dept Radiat Oncol, Tucson, AZ 85724 USA
[2] VA N Texas Hlth Care Syst, Dept Radiol, Dallas, TX USA
[3] VA N Texas Hlth Care Syst, Dept Dietet Serv, Dallas, TX USA
[4] VA N Texas Hlth Care Syst, Dept Radiat Oncol, Dallas, TX USA
[5] Univ So Calif, Dept Radiat Oncol, Los Angeles, CA 90089 USA
[6] Albert Einstein Univ, Dept Radiat Oncol, New York, NY USA
[7] Ctr Val Aurelle, Dept Radiat Oncol, Montpellier, France
[8] VA Med Ctr, Dept Radiat Oncol, Cleveland, OH USA
[9] ChemRisk, Houston, TX USA
[10] NovoNordisk, Div Hematol Res, Athens, Greece
来源：
ANTICANCER RESEARCH | 2007年 / 27卷 / 3B期
关键词：
aspiration; chemoradiation; pneumonia; swallow; head and neck cancer;
D O I：
暂无
中图分类号：
R73 [肿瘤学];
学科分类号：
100214 ;
摘要：
Aim: To assess the risk of developing aspiration during chemoradiation for head and neck cancer. Patients and Methods: A retrospective review of 114 patients who underwent concurrent chemoradiation for locally advanced head and neck cancer was undertaken. Patients were determined as having aspiration if they had pneumonia on chest-X-ray (CXR) and/or had documented aspiration on the modified barium swallow (MBS) during their treatment. Results: Fifteen patients (13%) developed aspiration during chemoradiation. Twelve patients (10%) had aspiration demonstrated on CXR alone (9 patients) or combined with MBS (3 patients). Three patients (3%) had aspiration on MBS alone. Three of the six patients with aspiration observed on MBS had normal swallowing on their pretreatment MBS. All 15 patients had severe mucositis and neutropenia at the time of the aspiration. Despite broad-spectrum antibiotics and supportive care, six patients (5%) died. Conclusion: Aspiration may develop during chemoradiation for head and neck cancer because of radiation-induced altered swallow.
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收藏
页码：1669 / 1672
页数：4
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