Basic Alumina-Catalyzed, Solvent-Free Synthesis of Diversified Thioethers

Environmentally and economically benign solvent free syntheses of thioethers are performed by the reaction of benzothiazole thiol with different halides on basic aluminaa simple, cheap, robust catalyst that couples a range of substrates with thiol in excellent yields in a short time. The in vitro antibacterial screening of compounds 3c, e, g, i, j, and k were evaluated against the Gram-positive organism Staphylococcus aureus and Gram-negative organisms. Escherichia coli and Proteus mirabilis by the Agar well diffusion method. Supplemental materials are available for this article. Go to the publisher's online edition of Phosphorus, Sulfur, and Silicon and the Related Elements to view the free supplemental file.