Adoptive transferred transferred hepatic stellate cells attenuated drug-induced liver injury by modulating the rate of regulatory T cells/T helper 17 cells

被引：6
作者：
Feng, Min [1 ]
Wang, Quanrongzi [2 ,3 ]
Jiang, Zhonghua [3 ]
Ding, Jie [1 ]
Wang, Hao [1 ]
Wang, Meng [1 ]
Lu, Ling [3 ]
Guan, Wenxian [1 ]
机构：
[1] Nanjing Univ, Affiliated Hosp, Nanjing Drum Tower Hosp, Med Sch,Dept Gen Surg, Nanjing, Jiangsu, Peoples R China
[2] Nanjing Med Univ, Affiliated Hosp 1, Dept Radiol, Nanjing 210029, Jiangsu, Peoples R China
[3] Minist Publ Hlth, Key Lab Living Donor Liver Transplantat, Nanjing 210029, Jiangsu, Peoples R China
来源：
CLINICAL IMMUNOLOGY | 2016年 / 165卷
基金：
中国国家自然科学基金;
关键词：
Regulatory T cells; Tregs; Hepatic stellate cells; T helper 17 cells; Th17; cells; ISCHEMIA-REPERFUSION INJURY; TRANS-RETINOIC ACID; TGF-BETA; HEPATOTOXICITY; ACTIVATION; MILIEU;
D O I：
10.1016/j.clim.2016.02.006
中图分类号：
R392 [医学免疫学]; Q939.91 [免疫学];
学科分类号：
100102 ;
摘要：
Our study showed that hepatic stellate cells (HSCs) promote the healing of the liver after drug-induced acute injury. However, the relevant mechanisms by which this is accomplished remain unclear. The objective of this study was to investigate the role of the adoptive transfer of HSCs in acute liver injury and the underlying mechanisms for healing. It was found that adoptive transfer of HSCs resulted in an increase in Tregs and a decrease in Th17 cells. Liver insult was consistently attenuated by HSC treatment. HSC cultured medium induced Tregs from naive T cells and suppressed the differentiation of Th17 cells. This study demonstrated that the adoptive transfer of HSCs protected the liver from drug-induced acute injury. Promoting the differentiation of Tregs and suppressing the development of Th17 cells are possibly involved in the protective effect of adoptive transfer of HSCs. (C) 2016 Elsevier Inc. All rights reserved.
引用
收藏
页码：12 / 18
页数：7
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