Microbiota and their role in the pathogenesis of oral mucositis

被引：82
作者：
Vanhoecke, B. [1 ,2 ]
De Ryck, T. [1 ,3 ]
Stringer, A. [2 ,4 ,5 ]
Van de Wiele, T. [1 ]
Keefe, D. [2 ]
机构：
[1] Univ Ghent, Lab Microbial Ecol & Technol, Fac Biosci Engn, B-9000 Ghent, Belgium
[2] Univ Adelaide, Mucositis Res Grp, Dept Med, Adelaide, SA 5000, Australia
[3] Univ Ghent, Dept Radiat Oncol & Expt Canc Res, Lab Expt Canc Res, B-9000 Ghent, Belgium
[4] Univ S Australia, Sch Pharm & Med Sci, Adelaide, SA 5001, Australia
[5] Univ Adelaide, Sch Med Sci, Adelaide, SA 5000, Australia
来源：
ORAL DISEASES | 2015年 / 21卷 / 01期
基金：
澳大利亚国家健康与医学研究理事会;
关键词：
oral; mucositis; microbiota; biofilm; radiotherapy; chemotherapy; PATIENTS RECEIVING RADIOTHERAPY; CHEMOTHERAPY-INDUCED MUCOSITIS; IRINOTECAN-INDUCED MUCOSITIS; GINGIVAL EPITHELIAL-CELLS; INTESTINAL MUCUS LAYER; NECK-CANCER PATIENTS; TOLL-LIKE RECEPTORS; GERM-FREE-MICE; DOUBLE-BLIND; SELECTIVE ELIMINATION;
D O I：
10.1111/odi.12224
中图分类号：
R78 [口腔科学];
学科分类号：
1003 ;
摘要：
Oral mucositis in patients undergoing cancer therapy is a significant problem. Its prevalence ranges between 20 and 100%, depending on treatment type and protocols and patient-based variables. Mucositis is self-limiting when uncomplicated by infection. Unfortunately, the incidence of developing a local or systemic infection during the course of the treatment is very high. At this stage, it is unclear which role oral microbiota play in the onset, duration, and severity of oral mucositis. Nevertheless, there is growing interest in this underexplored topic, and new studies are being undertaken to unravel their impact on the pathogenesis of mucositis.
引用
收藏
页码：17 / 30
页数：14
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