Soluble CD86 is a costimulatory molecule for human T lymphocytes

被引：116

作者：

Jeannin, P

Magistrelli, G

Aubry, JP

Caron, G

Gauchat, JF

Renno, T

Herbault, N

Goetsch, L

Blaecke, A

Dietrich, PY

Bonnefoy, JY

Delneste, Y

机构：

[1] Ctr Immunol Pierre Fabre, F-74164 St Julien En Genevois, France

[2] Hop Cantonal Univ Geneva, Lab Immunol Tumeurs, CH-1124 Geneva, Switzerland

来源：

IMMUNITY | 2000年 / 13卷 / 03期

关键词：

D O I：

10.1016/S1074-7613(00)00030-3

中图分类号：

R392 [医学免疫学]; Q939.91 [免疫学];

学科分类号：

100102 ;

摘要：

CD86 is an important costimulatory molecule for the priming and activation of naive and memory T cells, respectively. Here, we show that soluble CD86 is detected in human serum. Soluble CD86 is produced by resting monocytes and results from an alternatively spliced transcript (CD86 Delta TM) characterized by deletion of the transmembrane domain. Recombinant CD86 Delta TM binds to CD28 and CTLA-4 and induces the activation of T cells after stimulation with anti-CDS mAb. CD86 Delta TM also induces IFN gamma production by virus-specific CD8(+) memory human T cells stimulated with the Flu M1 peptide. The concentrations of soluble CD86 found in human serum are sufficient to induce biological activity. Soluble CD86 molecule, therefore, appears to be a functional costimulatory molecule playing a potentially important role in immune surveillance.

引用

页码：303 / 312

页数：10

共 57 条

[51] EFFICIENT AND RAPID AFFINITY PURIFICATION OF PROTEINS USING RECOMBINANT FUSION PROTEASES [J].

WALKER, PA ;

LEONG, LEC ;

NG, PWP ;

TAN, SH ;

WALLER, S ;

MURPHY, D ;

PORTER, AG .

BIO-TECHNOLOGY, 1994, 12 (06) :601-605

[52] CTLA-4 CAN FUNCTION AS A NEGATIVE REGULATOR OF T-CELL ACTIVATION [J].

WALUNAS, TL ;

LENSCHOW, DJ ;

BAKKER, CY ;

LINSLEY, PS ;

FREEMAN, GJ ;

GREEN, JM ;

THOMPSON, CB ;

BLUESTONE, JA .

IMMUNITY, 1994, 1 (05) :405-413

[53]

YOKOCHI T, 1982, J IMMUNOL, V128, P823

[54] Functional CD86 (B7-2/B70) on cultured human Langerhans cells [J].

Yokozeki, H ;

Katayama, I ;

Ohki, O ;

Matsunaga, T ;

Watanabe, K ;

Satoh, T ;

Azuma, M ;

Okumura, K ;

Nishioka, K .

JOURNAL OF INVESTIGATIVE DERMATOLOGY, 1996, 106 (01) :147-153

[55] T-cell co-stimulation through B7RP-1 and ICOS [J].

Yoshinaga, SK ;

Whoriskey, JS ;

Khare, SD ;

Sarmiento, U ;

Guo, J ;

Horan, T ;

Shih, G ;

Zhang, M ;

Coccia, MA ;

Kohno, T ;

Tafuri-Bladt, A ;

Brankow, D ;

Campbell, P ;

Chang, D ;

Chiu, L ;

Dai, TN ;

Duncan, G ;

Elliott, GS ;

Hui, A ;

McCabe, SM ;

Scully, S ;

Shahinian, A ;

Shaklee, CL ;

Van, G ;

Mak, TW ;

Senaldi, G .

NATURE, 1999, 402 (6763) :827-832

[56] Differential requirements for co-stimulatory signals from B7 family members by resting versus recently activated memory T cells towards soluble recall antigens [J].

Zhang, YQ ;

vanNeerven, RJJ ;

Kasran, A ;

deBoer, M ;

Ceuppens, JL .

INTERNATIONAL IMMUNOLOGY, 1996, 8 (01) :37-44

[57] On immunological memory [J].

Zinkernagel, RM ;

Bachmann, MF ;

Kundig, TM ;

Oehen, S ;

Pirchet, H ;

Hengartner, H .

ANNUAL REVIEW OF IMMUNOLOGY, 1996, 14 :333-367

← 1 2 3 4 5 6 →