A model for the involvement of neural cell adhesion molecules in stress-related mood disorders

被引:61
作者
Sandi, Carmen [1 ]
Bisaz, Reto [1 ]
机构
[1] Ecole Polytech Fed Lausanne, Brain Mind Inst, AAB, CH-1015 Lausanne, Switzerland
关键词
depression; network hypothesis of depression; neural cell adhesion molecules; L1; NCAM; PSA-NCAM; neurocircuitry structure and function; neurotrophins and growth factors; stress-related mood disorders; antidepressant; neurogenesis; BDNF; structural remodeling; chronic stress; LONG-TERM POTENTIATION; FIBROBLAST GROWTH FACTOR-2; CHRONIC RESTRAINT STRESS; NEUROTROPHIC FACTOR EXPRESSION; HIPPOCAMPAL PROGENITOR CELLS; SUBGENUAL PREFRONTAL CORTEX; SYNTHETIC PEPTIDE LIGAND; TRKB MESSENGER-RNA; MAJOR DEPRESSION; POLYSIALIC ACID;
D O I
10.1159/000101535
中图分类号
R5 [内科学];
学科分类号
1002 ; 100201 ;
摘要
Critical interactions between genetic and environmental factors - among which stress is one of the most potent non-genomic factors - are involved in the development of mood disorders. Intensive work during the past decade has led to the proposal of the network hypothesis of depression [Castren E: Nat Rev Neurosci 2005; 6: 241 - 246]. In contrast to the earlier chemical hypothesis of depression that emphasized neurochemical imbalance as the cause of depression, the network hypothesis proposes that problems in information processing within relevant neural networks might underlie mood disorders. Clinical and preclinical evidence supporting this hypothesis are mainly based on observations from depressed patients and animal stress models indicating atrophy (with basic research pointing at structural remodeling and decreased neurogenesis as underlying mechanisms) and malfunctioning of the hippocampus and prefrontal cortex, as well as the ability of antidepressant treatments to have the opposite effects. A great research effort is devoted to identify the molecular mechanisms that are responsible for the network effects of depression and antidepressant actions, with a great deal of evidence pointing at a key role of neurotrophins (notably the brain-derived neurotrophic factor) and other growth factors. In this review, we present evidence that implicates alterations in the levels of the neural cell adhesion molecules of the immunoglobulin superfamily, NCAM and L1, among the mechanisms contributing to stress-related mood disorders and, potentially, in antidepressant action. Copyright (c) 2007 S. Karger AG, Basel
引用
收藏
页码:158 / 176
页数:19
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