Recruitment to stalled replication forks of the PriA DNA helicase and replisome-loading activities is essential for survival

被引：80
作者：
Gabbai, Carolina B. [2 ]
Marians, Kenneth J. [1 ,2 ]
机构：
[1] Mem Sloan Kettering Canc Ctr, Program Mol Biol, New York, NY 10021 USA
[2] Weill Cornell Grad Sch Med Sci, Program Mol Biol, New York, NY USA
来源：
DNA REPAIR | 2010年 / 9卷 / 03期
关键词：
DNA replication restart; PriA helicase; Recombination; Primosome; ESCHERICHIA-COLI K-12; PHI X174-TYPE PRIMOSOME; SINGLE-STRANDED-DNA; H-DEFECTIVE MUTANTS; PROTEIN PRIA; LAGGING-STRAND; HOMOLOGOUS RECOMBINATION; RESTART PRIMOSOME; DEPENDENT ATPASE; LEADING-STRAND;
D O I：
10.1016/j.dnarep.2009.12.009
中图分类号：
Q3 [遗传学];
学科分类号：
071007 ; 090102 ;
摘要：
PriA, a 3' -> 5' superfamily 2 DNA helicase, acts to remodel stalled replication forks and as a specificity factor for origin-independent assembly of a new replisome at the stalled fork. The ability of PriA to initiate replication at stalled forked structures ensures complete genome replication and helps to protect the cell from illegitimate recombination events. This review focuses on the activities of PriA and its role in replication fork assembly and maintaining genomic integrity. (C) 2010 Elsevier B.V. All rights reserved.
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收藏
页码：202 / 209
页数：8
相关论文
共 88 条
[1]   Modulation of recombination and DNA repair by the RecG and PriA helicases of Escherichia coli K-12 [J].
AlDeib, AA ;
Mahdi, AA ;
Lloyd, RG .
JOURNAL OF BACTERIOLOGY, 1996, 178 (23) :6782-6789
[2]  
ALLEN GC, 1993, J BIOL CHEM, V268, P19204
[3]  
Arber W., 1971, BACTERIOPHAGE LAMBDA, P83
[4]   HOMOLOGOUS RECOMBINATION-DEPENDENT INITIATION OF DNA-REPLICATION FROM DNA DAMAGE-INDUCIBLE ORIGINS IN ESCHERICHIA-COLI [J].
ASAI, T ;
SOMMER, S ;
BAILONE, A ;
KOGOMA, T .
EMBO JOURNAL, 1993, 12 (08) :3287-3295
[5]   D-LOOPS AND R-LOOPS - ALTERNATIVE MECHANISMS FOR THE INITIATION OF CHROMOSOME-REPLICATION IN ESCHERICHIA-COLI [J].
ASAI, T ;
KOGOMA, T .
JOURNAL OF BACTERIOLOGY, 1994, 176 (07) :1807-1812
[6]   Functional interplay between the Bacillus subtilis DnaD and DnaB proteins essential for initiation and re-initiation of DNA replication [J].
Bruand, C ;
Velten, M ;
McGovern, S ;
Marsin, S ;
Sérèna, C ;
Ehrlich, SD ;
Polard, P .
MOLECULAR MICROBIOLOGY, 2005, 55 (04) :1138-1150
[7]   DnaB, DnaD and DnaI proteins are components of the Bacillus subtilis replication restart primosome [J].
Bruand, C ;
Farache, M ;
McGovern, S ;
Ehrlich, SD ;
Polard, P .
MOLECULAR MICROBIOLOGY, 2001, 42 (01) :245-255
[8]   PriB stimulates PriA helicase via an interaction with single-stranded DNA [J].
Cadman, CJ ;
Lopper, M ;
Moon, PB ;
Keck, JL ;
McGlynn, P .
JOURNAL OF BIOLOGICAL CHEMISTRY, 2005, 280 (48) :39693-39700
[9]   PriA helicase and SSB interact physically and functionally [J].
Cadman, CJ ;
McGlynn, P .
NUCLEIC ACIDS RESEARCH, 2004, 32 (21) :6378-6387
[10]   UV irradiation induces a postreplication DNA damage checkpoint [J].
Callegari, A. John ;
Kelly, Thomas J. .
PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA, 2006, 103 (43) :15877-15882
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