Finding a place for tumor-specific T cells in targeted cancer therapy

被引：20

作者：

Riddell, SR ^{[1
]}

机构：

[1] Univ Washington, Fred Hutchinson Canc Res Ctr, Dept Med, Div Clin Res,Program Immunol, Seattle, WA 98109 USA

来源：

JOURNAL OF EXPERIMENTAL MEDICINE | 2004年 / 200卷 / 12期

关键词：

D O I：

10.1084/jem.20042004

中图分类号：

R392 [医学免疫学]; Q939.91 [免疫学];

学科分类号：

100102 ;

摘要：

A goal in cancer therapeutics is to develop targeted modalities that distinguish malignant from normal cells. T cells can discriminate diseased cells based on subtle alterations in peptides displayed in association with MHC molecules at the cell surface. Recent success using the adoptive transfer of tumor-specific T cells has fueled optimism that this approach may find a place as a targeted therapy for some human cancers.

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收藏

页码：1533 / 1537

页数：5

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