Assessing intraepithelial neoplasia and drug safety in cancer-preventive drug development

被引：15

作者：

Kelloff, Gary J.

Sigman, Caroline C.

机构：

[1] Natl Inst Hlth, Natl Canc Inst, Div Canc Treatment & Diag, Rockville, MD 20852 USA

[2] CCS Assoc, Mountain View, CA 94043 USA

来源：

NATURE REVIEWS CANCER | 2007年 / 7卷 / 07期

关键词：

D O I：

10.1038/nrc2154

中图分类号：

R73 [肿瘤学];

学科分类号：

100214 ;

摘要：

Despite significant interest from the research community and the population in general, drug approvals for cancer prevention and/ or cancer risk reduction are few. This is due, in part, to the requirement that new cancer-preventive drugs must first be shown to be efficacious in reducing cancer incidence or mortality. Moreover, such drugs need to have proven safety for long-term administration. This process can be improved by focusing on precancer ( intraepithelial neoplasia) to identify subjects at risk and prove efficacy in shorter, smaller trials as well as on detecting early markers of potential toxicities of chronic exposure to cancer-preventive drug regimens.

引用

页码：508 / 518

页数：11

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