Dock2 in the development of inflammation and cancer

被引：37

作者：

Chen, Yayun ^{[1
]}

Meng, Fan ^{[2
,3
,4
]}

Wang, Bingyu ^{[1
]}

He, Liangmei ^{[4
]}

Liu, Yangbin ^{[1
]}

Liu, Zhiping ^{[1
,5
]}

机构：

[1] Gannan Med Univ, Sch Basic Med, Ganzhou 341000, Jiangxi, Peoples R China

[2] Southern Med Univ, Guangzhou, Guangdong, Peoples R China

[3] Guangdong Acad Med Sci, Guangdong Gen Hosp, Guangzhou, Guangdong, Peoples R China

[4] Gannan Med Univ, Affiliated Hosp 1, Ganzhou, Jiangxi, Peoples R China

[5] Ganzhou Canc Precis Med Engn Res Ctr, Ganzhou, Jiangxi, Peoples R China

来源：

EUROPEAN JOURNAL OF IMMUNOLOGY | 2018年 / 48卷 / 06期

基金：

中国国家自然科学基金;

关键词：

Cancer; Dock2; Inflammation; Rac; RAC ACTIVATOR DOCK2; PLASMACYTOID DENDRITIC CELLS; NUCLEOTIDE-EXCHANGE FACTORS; RHO-GTPASES; T-CELLS; CYTOSKELETAL REORGANIZATION; NEUTROPHIL CHEMOTAXIS; LYMPHOCYTE MIGRATION; FAMILY PROTEINS; REGULATOR;

D O I：

10.1002/eji.201747157

中图分类号：

R392 [医学免疫学]; Q939.91 [免疫学];

学科分类号：

100102 ;

摘要：

An atypical guanine exchange factor, Dock2 is specifically expressed in hematopoietic cells and regulates activation and migration of immune cells through activating Ras-related C3 botulinum toxin substrate (Rac). Dock2 was shown to be critical in the development of various inflammatory diseases, including allergic diseases, HIV infection, and graft rejection in organ transplantation. DOCK2 mutation in infants was recently identified to be associated with T and B cell combined immunodeficiency. Furthermore, Dock2 is involved in host protection during enteric bacterial infection and is also associated with the proliferation of cancer cells. It was also shown that patients with digestive tract cancer had high frequency mutation of DOCK2. This review summarizes the latest research progresses on the role of Dock2 for the development of various inflammatory diseases and cancers, and discusses the potential application of Dock2 modulators for patient treatment.

引用

页码：915 / 922

页数：8

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