Up-regulation of Connexin43 in the glial scar following photothrombotic ischemic injury

被引：72

作者：

Haupt, Corinna ^{[1
]}

Witte, Otto W. ^{[1
]}

Frahm, Christiane ^{[1
]}

机构：

[1] Univ Jena, Dept Neurol, D-07747 Jena, Germany

来源：

MOLECULAR AND CELLULAR NEUROSCIENCE | 2007年 / 35卷 / 01期

关键词：

reactive astrocytes; gap junctions; astrogliosis; GFAP; nestin; BrdU; in situ hybridization;

D O I：

10.1016/j.mcn.2007.02.005

中图分类号：

Q189 [神经科学];

学科分类号：

071006 ;

摘要：

Several types of CNS injury and various diseases are associated with the development of a glial scar. Astrocytes are major components of the glial scar. They are interconnected by gap junctions, with connexin43 (Cx43) being the most prominent channel protein. We applied a model of focal cerebral ischemia to study the spatio-temporat expression of glial fibrillary acidic protein, as well as of Cx43 mRNA and protein in gliotic tissue up to 60 days after injury. Reactive astrocytes enveloping the lesion up-regulated their Cx43 mRNA and protein. A band of reactive astrocytes filling in the lesion exhibited elevated Cx43 and showed a high degree of proliferation. Because of these findings, we hypothesize a role for Cx43 in glial scar formation, specifically in the proliferation of astrocytes. (C) 2007 Elsevier Inc. All rights reserved.

引用

页码：89 / 99

页数：11

共 46 条

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