NuRD and SIN3 - histone deacetylase complexes in development

被引：314

作者：

Ahringer, J ^{[1
]}

机构：

[1] Wellcome CRC Inst, Cambridge CB2 1QR, England

来源：

TRENDS IN GENETICS | 2000年 / 16卷 / 08期

基金：

英国惠康基金;

关键词：

D O I：

10.1016/S0168-9525(00)02066-7

中图分类号：

Q3 [遗传学];

学科分类号：

071007 ; 090102 ;

摘要：

Transcription repression mediated through histone deacetylase (HDAC) complexes is widespread, and mechanisms by which HDAC complexes act have been revealed by extensive studies in vitro and in cell culture. However, until recently, little has been known about the developmental roles of histone deacetylation, Mutants now exist for a number of members of the two major HDAC complexes (NuRD and SIN3) and some associated proteins. The emerging picture is that these complexes have specific functions in development, rather than being required for most cellular processes.

引用

页码：351 / 356

页数：6

共 63 条

[1]

Aasland R, 1996, TRENDS BIOCHEM SCI, V21, P87, DOI 10.1016/0968-0004(96)30009-1

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