Development and validation of quick Acute Kidney Injury-score (q-AKI) to predict acute kidney injury at admission to a multidisciplinary intensive care unit

被引：11

作者：

Ferrari, Fiorenza ^{[1
,2
,3
,4
]}

Puci, Mariangela Valentina ^{[5
]}

Ferraro, Ottavia Eleonora ^{[5
]}

Romero-Gonzalez, Gregorio ^{[1
,2
,6
]}

Husain-Syed, Faeq ^{[1
,2
,7
]}

Rizo-Topete, Lilia ^{[1
,2
,8
,9
]}

Senzolo, Mara ^{[1
,2
]}

Lorenzin, Anna ^{[1
,2
]}

Muraro, Eva ^{[1
,2
,10
]}

Baracca, Antonio ^{[11
]}

Serrano-Soto, Mara ^{[1
,2
,12
]}

Molano Trivino, Alejandra ^{[1
,2
,13
]}

Castro, Ana Coutinho ^{[1
,2
,14
]}

De Cal, Massimo ^{[1
,2
]}

Corradi, Valentina ^{[1
,2
]}

Brendolan, Alessandra ^{[1
,2
]}

Scarpa, Marta ^{[1
,2
,3
]}

Carta, Maria Rosa ^{[15
]}

Giavarina, Davide ^{[15
]}

Bonato, Raffaele ^{[3
]}

Iotti, Giorgio Antonio ^{[4
]}

Ronco, Claudio ^{[1
,2
]}

机构：

[1] San Bortolo Hosp, IRRIV, Viale Rodolfi, Vicenza, Italy

[2] San Bortolo Hosp, Dept Nephrol Dialysis & Transplantat, Viale Rodolfi, Vicenza, Italy

[3] San Bortolo Hosp, Intens Care Unit, Viale Rodolfi, Vicenza, Italy

[4] IRCCS Policlin San Matteo, Intens Care Unit, Viale Golgi, Pavia, Italy

[5] Univ Pavia, Dept Publ Hlth Expt & Forens Med, Unit Biostat & Clin Epidemiol, Via Forlanini, Pavia, Italy

[6] RTS SAS, Medellin, Colombia

[7] Univ Clin Giessen & Marburg, Dept Internal Med 2, Div Pulmonol Nephrol & Crit Care Med, Campus Giessen, Giessen, Germany

[8] Univ Hosp Jose Eleuterio Gonzalez, Francisco I Madero S-N, Monterrey, Nuevo Leon, Mexico

[9] Gonzalitos Colonia Mitras Ctr, Monterrey, Nuevo Leon, Mexico

[10] Univ Padua, DISCOG Dept Surg Kidney & Pancreas Transplant, Padua, Italy

[11] abcGo Srl, Viale Merello, Cagliari, Italy

[12] Marques de Valdecilla Univ Hosp, Serv Nephrol, Santander, Cantabria, Spain

[13] Fdn Cardioinfantil, Nephrol & Dialysis Serv RTS, Bogota, Colombia

[14] Oporto Hosp Ctr Largo Prof Abel Salazar, Dept Nephrol Dialysis & Transplantat, Porto, Portugal

[15] San Bortolo Hosp, Dept Lab Med, Vicenza, Italy

来源：

PLOS ONE | 2019年 / 14卷 / 06期

关键词：

CRITICALLY-ILL PATIENTS; RENAL-FUNCTION; OBESITY; CLASSIFICATION; MORTALITY; RECOVERY; DIALYSIS; PRESSURE; THERAPY; RIFLE;

D O I：

10.1371/journal.pone.0217424

中图分类号：

O [数理科学和化学]; P [天文学、地球科学]; Q [生物科学]; N [自然科学总论];

学科分类号：

07 ; 0710 ; 09 ;

摘要：

AKI is associated with increased risk of death, prolonged length of stay and development of de-novo chronic kidney disease. The aim of our study is the development and validation of prediction models to identify the risk of AKI in ICU patients up to 7 days. We retrospectively recruited 692 consecutive patients admitted to the ICU at San Bortolo Hospital (Vicenza, Italy) from 1 June 2016 to 31 March 2017: 455 patients were treated as the derivation group and 237 as the validation group. Candidate variables were selected based on a literature review and expert opinion. Admission eGFR<90 ml/min /1.73 mq (OR 2.78; 95% CI 1.78-4.35; p<0.001); SOFAcv >= 2 (OR 2.23; 95% CI 1.48-3.37; p<0.001); lactate >= 2 mmol/L (OR 1.81; 95% CI 1.19-2.74; p = 0.005) and (TIMP-2).(IGFBP7) >= 0.3 (OR 1.65; 95% CI 1.08-2.52; p = 0.019) were significantly associated with AKI. For the q-AKI score, we stratified patients into different AKI Risk score levels: 0-2; 3-4; 5-6; 7-8 and 9-10. In both cohorts, we observed that the proportion of AKI patients was higher in the higher score levels.

引用

页数：10

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