Parkinson's disease biomarkers: perspective from the NINDS Parkinson's Disease Biomarkers Program

被引：49

作者：

Gwinn, Katrina ^{[1
]}

David, Karen K. ^{[1
]}

Swanson-Fischer, Christine ^{[1
]}

Albin, Roger ^{[2
,3
]}

St Hillaire-Clarke, Coryse ^{[4
]}

Sieber, Beth-Anne ^{[1
]}

Lungu, Codrin ^{[1
]}

Bowman, F. DuBois ^{[5
]}

Alcalay, Roy N.

Babcock, Debra ^{[1
]}

Dawson, Ted M. ^{[6
]}

Dewey, Richard B., Jr. ^{[7
]}

Foroud, Tatiana ^{[8
]}

German, Dwight ^{[9
]}

Huang, Xuemei ^{[10
]}

Petyuk, Vlad ^{[11
]}

Potashkin, Judith A. ^{[12
]}

Saunders-Pullman, Rachel ^{[13
]}

Sutherland, Margaret ^{[1
]}

Walt, David R. ^{[14
]}

West, Andrew B. ^{[15
]}

Zhang, Jing ^{[16
]}

Chen-Plotkin, Alice ^{[17
]}

Scherzer, Clemens R. ^{[18
]}

Vaillancourt, David E. ^{[19
,20
]}

Rosenthal, Liana S. ^{[21
]}

机构：

[1] NINDS, NIH, Bldg 36,Rm 4D04, Bethesda, MD 20892 USA

[2] Univ Michigan, Neurol Serv, Ann Arbor, MI 48109 USA

[3] Univ Michigan, GRECC, VAAAHS, UM Udall Ctr, Ann Arbor, MI 48109 USA

[4] NIA, NIH, Bethesda, MD 20892 USA

[5] Mailman Sch Publ Hlth, Dept Biostat, Columbia, MO USA

[6] Johns Hopkins Univ, Inst Cell Engn, Solomon H Snyder Dept Neurosci Pharmacol & Mol Sc, Neuroregenerat & Stem Cell Programs, Baltimore, MD 21218 USA

[7] Univ Texas Southwestern Med Ctr Dallas, Dept Neurol & Neurotherapeut, Dallas, TX 75390 USA

[8] Indiana Univ Sch Med, Dept Med & Mol Genet, Indianapolis, IN 46202 USA

[9] Univ Texas Southwestern Med Ctr Dallas, Dept Psychiat, Dallas, TX 75390 USA

[10] Penn State Hershey Med Ctr, Dept Neurol, Hershey, PA USA

[11] Pacific Northwest Natl Lab, Biol Sci Div, Richland, WA 99352 USA

[12] Rosalind Franklin Univ Med & Sci, Dept Cellular & Mol Pharmacol, N Chicago, IL USA

[13] Mt Sinai Beth Israel & Icahn Sch Med Mt Sinai, Dept Neurol, New York, NY USA

[14] Tufts Univ, Dept Chem, Medford, MA 02155 USA

[15] Univ Alabama Birmingham, Dept Neurol, UAB Stn, Birmingham, AL 35294 USA

[16] Univ Washington, Dept Pathol, Seattle, WA 98195 USA

[17] Univ Penn, Dept Neurol, Philadelphia, PA 19104 USA

[18] Harvard Med Sch, Brigham Womens Hosp, Dept Neurol, Cambridge, MA USA

[19] Univ Florida, Dept Appl Physiol, Gainesville, FL USA

[20] Univ Florida, Dept Kinesiol, Gainesville, FL USA

[21] Johns Hopkins Univ, Sch Med, Dept Neurol, Baltimore, MD 21205 USA

来源：

BIOMARKERS IN MEDICINE | 2017年 / 11卷 / 06期

基金：

美国国家卫生研究院;

关键词：

biomarkers; NINDS; Parkinson's disease; PDBP; PREDICTS COGNITIVE DECLINE; CEREBROSPINAL-FLUID; DOPAMINERGIC DEGENERATION; NEUROLOGICAL DISORDERS; NIGRAL HYPERINTENSITY; CLINICAL-DIAGNOSIS; NATIONAL INSTITUTE; SUBSTANTIA-NIGRA; AMYLOID-BETA; FREE-WATER;

D O I：

10.2217/bmm-2016-0370

中图分类号：

R-3 [医学研究方法]; R3 [基础医学];

学科分类号：

1001 ;

摘要：

Biomarkers for Parkinson's disease (PD) diagnosis, prognostication and clinical trial cohort selection are an urgent need. While many promising markers have been discovered through the National Institute of Neurological Disorders and Stroke Parkinson's Disease Biomarker Program (PDBP) and other mechanisms, no single PD marker or set of markers are ready for clinical use. Here we discuss the current state of biomarker discovery for platforms relevant to PDBP. We discuss the role of the PDBP in PD biomarker identification and present guidelines to facilitate their development. These guidelines include: harmonizing procedures for biofluid acquisition and clinical assessments, replication of the most promising biomarkers, support and encouragement of publications that report negative findings, longitudinal follow-up of current cohorts including the PDBP, testing of wearable technologies to capture readouts between study visits and development of recently diagnosed (de novo) cohorts to foster identification of the earliest markers of disease onset.

引用

页码：451 / 473

页数：23

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