Targeting sialic acid-Siglec interactions to reverse immune suppression in cancer

被引：114
作者：
Adams, Olivia Joan [1 ]
Stanczak, Michal A. [2 ]
von Gunten, Stephan [1 ]
Laubli, Heinz [2 ,3 ]
机构：
[1] Univ Bern, Inst Pharmacol, Inselspital INO F, CH-3010 Bern, Switzerland
[2] Univ Hosp Basel, Dept Biomed, Lab Canc Immunol, Petersgraben 4, CH-4031 Basel, Switzerland
[3] Univ Hosp Basel, Dept Internal Med, Med Oncol, Petersgraben 4, CH-4031 Basel, Switzerland
来源：
GLYCOBIOLOGY | 2018年 / 28卷 / 09期
基金：
瑞士国家科学基金会;
关键词：
blocking antibodies; cancer immunotherapy; hypersialylation; immune evasion; N-acetyl-neuraminic acid; N-glycolylneuraminic acid; GROUP-B STREPTOCOCCUS; REGULATORY T-CELLS; CD33-RELATED SIGLECS; RAPID EVOLUTION; BINDING SPECIFICITIES; ANTIIDIOTYPE ANTIBODY; SIALYLATED GLYCANS; O-ACETYLATION; N-GLYCOLYL; IN-VIVO;
D O I：
10.1093/glycob/cwx108
中图分类号：
Q5 [生物化学]; Q7 [分子生物学];
学科分类号：
071010 ; 081704 ;
摘要：
Changes in sialic acids in cancer have been observed for many years. In particular, the increase of sialoglycan density or hypersialylation in tumors has been described. Recent studies have identified mechanisms for immune evasion based on sialoglycan interactions with immunoregulatory Siglec receptors that are exploited by tumor cells and microorganisms alike. Siglecs are mostly inhibitory receptors similar to known immune checkpoints including PD-1 or CTLA-4 that are successfully targeted with blocking antibodies for cancer immunotherapy. Here, we summarize the known changes of sialic acids in cancer and the role Siglec receptors play in cancer immunity. We also focus on potential ways to target these Siglec receptors or sialoglycans in order to improve anti-cancer immunity.
引用
收藏
页码：640 / 647
页数：8
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