Targeting sialic acid-Siglec interactions to reverse immune suppression in cancer

被引：116

作者：

Adams, Olivia Joan ^{[1
]}

Stanczak, Michal A. ^{[2
]}

von Gunten, Stephan ^{[1
]}

Laubli, Heinz ^{[2
,3
]}

机构：

[1] Univ Bern, Inst Pharmacol, Inselspital INO F, CH-3010 Bern, Switzerland

[2] Univ Hosp Basel, Dept Biomed, Lab Canc Immunol, Petersgraben 4, CH-4031 Basel, Switzerland

[3] Univ Hosp Basel, Dept Internal Med, Med Oncol, Petersgraben 4, CH-4031 Basel, Switzerland

来源：

GLYCOBIOLOGY | 2018年 / 28卷 / 09期

基金：

瑞士国家科学基金会;

关键词：

blocking antibodies; cancer immunotherapy; hypersialylation; immune evasion; N-acetyl-neuraminic acid; N-glycolylneuraminic acid; GROUP-B STREPTOCOCCUS; REGULATORY T-CELLS; CD33-RELATED SIGLECS; RAPID EVOLUTION; BINDING SPECIFICITIES; ANTIIDIOTYPE ANTIBODY; SIALYLATED GLYCANS; O-ACETYLATION; N-GLYCOLYL; IN-VIVO;

D O I：

10.1093/glycob/cwx108

中图分类号：

Q5 [生物化学]; Q7 [分子生物学];

学科分类号：

071010 ; 081704 ;

摘要：

Changes in sialic acids in cancer have been observed for many years. In particular, the increase of sialoglycan density or hypersialylation in tumors has been described. Recent studies have identified mechanisms for immune evasion based on sialoglycan interactions with immunoregulatory Siglec receptors that are exploited by tumor cells and microorganisms alike. Siglecs are mostly inhibitory receptors similar to known immune checkpoints including PD-1 or CTLA-4 that are successfully targeted with blocking antibodies for cancer immunotherapy. Here, we summarize the known changes of sialic acids in cancer and the role Siglec receptors play in cancer immunity. We also focus on potential ways to target these Siglec receptors or sialoglycans in order to improve anti-cancer immunity.

引用

页码：640 / 647

页数：8

共 101 条

[1] An anti-idiotype vaccine elicits a specific response to N-glycolyl sialic acid residues of glycoconjugates in melanoma patients [J].

Alfonso, M ;

Díaz, A ;

Hernández, AM ;

Pérez, A ;

Rodríguez, E ;

Bitton, R ;

Pérez, R ;

Vázquez, AM .

JOURNAL OF IMMUNOLOGY, 2002, 168 (05) :2523-2529

[2] Siglec-5 and Siglec-14 are polymorphic paired receptors that modulate neutrophil and amnion signaling responses to group B Streptococcus [J].

Ali, Syed Raza ;

Fong, Jerry J. ;

Carlin, Aaron F. ;

Busch, Tamara D. ;

Linden, Rebecka ;

Angata, Takashi ;

Areschoug, Thomas ;

Parast, Mana ;

Varki, Nissi ;

Murray, Jeffrey ;

Nizet, Victor ;

Varki, Ajit .

JOURNAL OF EXPERIMENTAL MEDICINE, 2014, 211 (06) :1231-1242

[3] Human risk of diseases associated with red meat intake: Analysis of current theories and proposed role for metabolic incorporation of a non-human sialic acid [J].

Alisson-Silva, Frederico ;

Kawanishi, Kunio ;

Varki, Ajit .

MOLECULAR ASPECTS OF MEDICINE, 2016, 51 :16-30

[4] System-wide genomic and biochemical comparisons of sialic acid biology among primates and rodents -: Evidence for two modes of rapid evolution [J].

Altheide, Tasha K. ;

Hayakawa, Toshiyuki ;

Mikkelsen, Tarjei S. ;

Diaz, Sandra ;

Varki, Nissi ;

Varki, Ajit .

JOURNAL OF BIOLOGICAL CHEMISTRY, 2006, 281 (35) :25689-25702

[5] Glycans in immune recognition and response [J].

Amon, Ron ;

Reuven, Eliran Moshe ;

Ben-Arye, Shani Leviatan ;

Padler-Karavani, Vered .

CARBOHYDRATE RESEARCH, 2014, 389 :115-122

[6] Large-scale sequencing of the CD33-related Siglec gene cluster in five mammalian species reveals rapid evolution by multiple mechanisms [J].

Angata, T ;

Margulies, EH ;

Green, ED ;

Varki, A .

PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA, 2004, 101 (36) :13251-13256

[7] Molecular diversity and evolution of the Siglec family of cell-surface lectins [J].

Angata, Takashi .

MOLECULAR DIVERSITY, 2006, 10 (04) :555-566

[8] T cell regulation mediated by interaction of soluble CD52 with the inhibitory receptor Siglec-10 [J].

Bandala-Sanchez, Esther ;

Zhang, Yuxia ;

Reinwald, Simone ;

Dromey, James A. ;

Lee, Bo-Han ;

Qian, Junyan ;

Boehmer, Ralph M. ;

Harrison, Leonard C. .

NATURE IMMUNOLOGY, 2013, 14 (07) :741-+

[9] The mucin MUC1 modulates the tumor immunological microenvironment through engagement of the lectin Siglec-9 [J].

Beatson, Richard ;

Tajadura-Ortega, Virginia ;

Achkova, Daniela ;

Picco, Gianfranco ;

Tsourouktsoglou, Theodora-Dorita ;

Klausing, Sandra ;

Hillier, Matthew ;

Maher, John ;

Noll, Thomas ;

Crocker, Paul R. ;

Taylor-Papadimitriou, Joyce ;

Burchell, Joy M. .

NATURE IMMUNOLOGY, 2016, 17 (11) :1273-1281

[10] Human CD22 Inhibits Murine B Cell Receptor Activation in a Human CD22 Transgenic Mouse Model [J].

Bednar, Kyle J. ;

Shanina, Elena ;

Ballet, Romain ;

Connors, Edward P. ;

Duan, Shiteng ;

Juan, Joana ;

Arlian, Britni M. ;

Kulis, Michael D. ;

Butcher, Eugene C. ;

Fung-Leung, Wai-Ping ;

Rao, Tadimeti S. ;

Paulson, James C. ;

Macauley, Matthew S. .

JOURNAL OF IMMUNOLOGY, 2017, 199 (09) :3116-3128

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