Behavioral and structural adaptations to stress

被引：69

作者：

Cameron, Heather A. ^{[1
]}

Schoenfeld, Timothy J. ^{[1
,2
]}

机构：

[1] NIMH, Sect Neuroplast, NIH, Bldg 35-3C915 MSC 3718,35 Convent Dr, Bethesda, MD 20892 USA

[2] Belmont Univ, Psychol Sci Dept, Nashville, TN 37212 USA

来源：

FRONTIERS IN NEUROENDOCRINOLOGY | 2018年 / 49卷

基金：

美国国家卫生研究院;

关键词：

Adult neurogenesis; Dentate gyrus; Hippocampus; Volume; Dendrites; Morphology; Stress; Behavioral adaptation; ADULT HIPPOCAMPAL NEUROGENESIS; CA3 PYRAMIDAL NEURONS; CORTICOTROPIN-RELEASING HORMONE; MAJOR DEPRESSIVE DISORDER; GENERATED GRANULE CELLS; RAT DENTATE GYRUS; ENVIRONMENTAL ENRICHMENT; SYNAPTIC PLASTICITY; RESTRAINT STRESS; ELECTROCONVULSIVE-THERAPY;

D O I：

10.1016/j.yfrne.2018.02.002

中图分类号：

R5 [内科学];

学科分类号：

1002 ; 100201 ;

摘要：

Unpredictable aversive experiences, or stressors, lead to changes in depression- and anxiety-related behavior and to changes in hippocampal structure including decreases in adult neurogenesis, granule cell and pyramidal cell dendritic morphology, and volume. Here we review the relationship between these behavioral and structural changes and discuss the possibility that these changes may be largely adaptive. Specifically, we suggest that new neurons in the dentate gyrus enhance behavioral adaptability to changes in the environment, biasing behavior in novel situations based on previous experience with stress. Conversely, atrophy-like changes in the hippocampus and decreased adult neurogenesis following chronic stress may serve to limit stress responses and stabilize behavior during chronic stress.

引用

页码：106 / 113

页数：8

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