Carotene-rich plant foods ingested with minimal dietary fat enhance the total-body vitamin A pool size in Filipino schoolchildren as assessed by stable-isotope-dilution methodology

被引:66
作者
Ribaya-Mercado, Judi D.
Maramag, Cherry C.
Tengco, Lorena W.
Dolnikowski, Gregory G.
Blumberg, Jeffrey B.
Solon, Florentino S.
机构
[1] Tufts Univ, Jean Mayer US Dept Agr Human Nutr Res Ctr, Boston, MA USA
[2] Nutr Ctr Philippines, Taguig, Philippines
关键词
vitamin A; deuterated-retinol dilution; stable-isotope dilution; retinol; plant carotenoids; beta-carotene; bioavailability; dietary fat; school-age children; Philippines;
D O I
10.1093/ajcn/85.4.1041
中图分类号
R15 [营养卫生、食品卫生]; TS201 [基础科学];
学科分类号
100403 ;
摘要
Background: Strategies for improving the vitamin A status of vulnerable populations are needed. Objective: We studied the influence of the amounts of dietary fat on the effectiveness of carotene-rich plant foods in improving vitamin A status. Design: Schoolchildren aged 9-12 y were fed standardized meals 3 times/d, 5 d/wk, for 9 wk. The meals provided 4.2 mg provitamin A carotenoids/d (mainly beta-carotene) from yellow and green leafy vegetables [carrots, pechay (bok choy), squash, and kangkong (swamp cabbage)] and 7, 15, or 29 g fat/d (2.4, 5, or 10 g fat/meal) in groups A, B, and C (n = 39, 39, and 38, respectively). Other self-selected foods eaten were recorded daily. Before and after the intervention, total-body vitamin A pool sizes and liver vitamin A concentrations were measured with the deuterated-retinol-dilution method; serum retinol and carotenoid concentrations were measured by HPLC. Results: Similar increases in mean serum beta-carotene (5-fold), alpha-carotene (19-fold), and beta-cryptoxanthin (2-fold) concentrations; total-body vitamin A pool size (2-fold); and liver vitamin A (2-fold) concentrations were observed after 9 wk in the 3 study groups; mean serum retinol concentrations did not change significantly. The total daily beta-carotene intake from study meals plus self-selected foods was similar between the 3 groups and was 14 times the usual intake; total fat intake was 0.9, 1.4, or 2.0 times the usual intake in groups A, 13, and C, respectively. The overall prevalence of low liver vitamin A (< 0.07 mu mol/g) decreased from 35% to 7%. Conclusions: Carotene-rich yellow and green leafy vegetables, when ingested with minimal fat, enhance serum carotenoids and the total-body vitamin A pool size and can restore low liver vitamin A concentrations to normal concentrations.
引用
收藏
页码:1041 / 1049
页数:9
相关论文
共 50 条
[1]  
[Anonymous], 2000, US
[2]  
BAUSCH J, 1977, ACTA VITAMINOL ENZYM, V31, P99
[3]   VARIABILITY OF SERUM CAROTENOIDS IN RESPONSE TO CONTROLLED DIETS CONTAINING 6 SERVINGS OF FRUITS AND VEGETABLES PER DAY [J].
BOWEN, PE ;
GARG, V ;
STACEWICZSAPUNTZAKIS, M ;
YELTON, L ;
SCHREINER, RS .
CAROTENOIDS IN HUMAN HEALTH, 1993, 691 :241-243
[4]   Carotenoid bioavailability is higher from salads ingested with full-fat than with fat-reduced salad dressings as measured with electrochemical detection [J].
Brown, MJ ;
Ferruzzi, MG ;
Nguyen, ML ;
Cooper, DA ;
Eldridge, AL ;
Schwartz, SJ ;
White, WS .
AMERICAN JOURNAL OF CLINICAL NUTRITION, 2004, 80 (02) :396-403
[5]   Orange fruit is more effective than are dark-green, leafy vegetables in increasing serum concentrations of retinol and β-carotene in schoolchildren in Indonesia [J].
de Pee, S ;
West, CE ;
Permaesih, D ;
Martuti ;
Muhilal ;
Hautvast, JGAJ .
AMERICAN JOURNAL OF CLINICAL NUTRITION, 1998, 68 (05) :1058-1067
[6]   LACK OF IMPROVEMENT IN VITAMIN-A STATUS WITH INCREASED CONSUMPTION OF DARK-GREEN LEAFY VEGETABLES [J].
DEPEE, S ;
WEST, CE ;
MUHILAL ;
KARYADI, D ;
HAUTVAST, JGAJ .
LANCET, 1995, 346 (8967) :75-81
[7]   INFLUENCE OF DIETARY VITAMIN A ON CAROTENOID UTILIZATION NITROGEN RETENTION AND ENERGY UTILIZATION BY CHICK [J].
DUA, PN ;
DAY, EJ ;
TIPTON, HC ;
HILL, JE .
JOURNAL OF NUTRITION, 1966, 90 (02) :117-&
[8]   ABSORPTION AND TRANSPORT OF CAROTENOIDS [J].
ERDMAN, JW ;
BIERER, TL ;
GUGGER, ET .
CAROTENOIDS IN HUMAN HEALTH, 1993, 691 :76-85
[9]  
*FOOD NUTR RES I D, 1997, PHIL FOOD COMP TABL
[10]  
*FOOD NUTR RES I D, 2001, PHIL NUTR FACTS FIG