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Univ Manchester, Univ Hosp S Manchester NHS Fdn Trust, Manchester Acad Hlth Sci Ctr, NIHR Translat Res Facil Resp Med, Manchester M23 9LT, Lancs, England Univ Manchester, Univ Hosp S Manchester NHS Fdn Trust, Manchester Acad Hlth Sci Ctr, NIHR Translat Res Facil Resp Med, Manchester M23 9LT, Lancs, England