Vitamin E-blended versus conventional polyethylene liners in prostheses: Prospective, randomized trial with 3-year follow-up

被引:0
作者
Busch, Andre [1 ]
Jaeger, Marcus [1 ,2 ]
Wegner, Alexander [1 ]
Haversath, Marcel [1 ]
Landgraeber, S. [3 ]
Serong, S. [3 ]
Haversath, M. [1 ]
von Wasen, A. [1 ]
Windhagen, H. [4 ]
Floerkemeier, T. [4 ]
Budde, S. [4 ]
Kubilay, J. [4 ]
Noll, Y. [4 ]
Delank, K. S. [5 ]
Baghdadi, J. [5 ]
Willburger, R. [6 ]
Duecker, M. [7 ]
Wilke, A. [8 ]
Huetter, F. [8 ]
机构
[1] Univ Duisburg Essen, Dept Orthopaed & Trauma Surg, Hufelandstr 55, D-45147 Essen, Germany
[2] Univ Duisburg Essen, Klin Orthopadie Unfall & Wiederherstellungschirur, St Marienhosp Mulhe, Contilia Grp, Essen, Germany
[3] Univ Saarland, Dept Orthopaed, Saarbrucken, Germany
[4] Hannover Med Sch, Klin Orthopadie, Diakovere Annastift, Hannover, Germany
[5] Univ Halle, Klin Orthopadie & Unfallchirurg, Halle, Germany
[6] Ruhr Univ Bochum, Kathol Klinikum Bochum, Orthopadie & Unfallchirurg, Bochum, Germany
[7] Marienhaus Klinikum St Josef, Klin Orthopadie, Bendorf, Germany
[8] Elisabeth Klin, Orthopadie Unfall Hand & Wiederherstellungschirug, Bigge Olsberg, Germany
来源
ORTHOPADE | 2020年 / 49卷 / 12期
关键词
Biomaterials; Antioxidant; Patient-related outcome measurement; Total hip replacement; Prosthesis durability; TOTAL HIP-ARTHROPLASTY; MOLECULAR-WEIGHT POLYETHYLENE; CROSS-LINKED POLYETHYLENE; ALPHA-TOCOPHEROL; TOTAL JOINT; REPLACEMENT; UHMWPE; WEAR; EPIDEMIOLOGY; DISLOCATION;
D O I
10.1007/s00132-019-03830-6
中图分类号
R826.8 [整形外科学]; R782.2 [口腔颌面部整形外科学]; R726.2 [小儿整形外科学]; R62 [整形外科学(修复外科学)];
学科分类号
摘要
BackgroundDespite continuous technical improvements, polyethylene wear debris induced periprosthetic osteolysis remains the main cause for failure of hip arthroplasty. Progressive oxidation of polyethylene was identified as another risk factor for material failure. To overcome this problem, antioxidants such as vitamin E (alpha-tocopherol) were supplemented by diffusion into the latest generation of polyethylene liners.ObjectiveThe purpose of the present study was to investigate the clinical outcome of patients treated with vitamin E blended highly cross-linked ultra-high molecular weight polyethylene liners (UHMWPE-XE) in comparison with conventional UHMWPE-X liners by evaluating patient-reported outcome measures (PROM's) at 3-year follow-up.MethodsA total of 143 patients were recruited into this prospective, randomized trial in our academic center. Three years after implantation, 101 patients were examined in the outpatient clinic for follow-up. Of these, 51 (50.5%) received UHMWPE-XE and 50 (49.5%) UHMWPE-X liners. Clinical outcome was evaluated using Harris-Hip-Score (HHS) UCLA-Score and Hip Disability and Osteoarthritis Outcome Score (HOOS).ResultsThere was a significant improvement in all PROM's at one- and three-year follow-up compared to the status before implantation. PROM's did not differ significantly between the first and third year follow-up. Both liner groups showed an equal clinical outcome.ConclusionThe present study demonstrates that the supplementation of vitamin E to polyethylene liners is reliable and safe without showing higher complication rates compared with conventional polyethylene liners. The shortterm clinical outcome of vitamin E-blended (UHMWPE-XE) is equivalent to those of conventional highly cross-linked polyethylene liners.
引用
收藏
页码:1077 / 1085
页数:9
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