A genetic polymorphism of MAO-B modifies the association of cigarette smoking and Parkinson's disease

被引：78
作者：
Checkoway, H
Franklin, GM
Costa-Mallen, P
Smith-Weller, T
Dilley, J
Swanson, PD
Costa, LG
机构：
[1] Univ Washington, Dept Environm Hlth, Seattle, WA 98195 USA
[2] Univ Washington, Dept Epidemiol, Seattle, WA 98195 USA
[3] Univ Washington, Dept Neurol, Seattle, WA 98195 USA
来源：
NEUROLOGY | 1998年 / 50卷 / 05期
关键词：
D O I：
10.1212/WNL.50.5.1458
中图分类号：
R74 [神经病学与精神病学];
学科分类号：
摘要：
In a population-based case-control study, we found a reversal of the association of cigarette smoking with Parkinson's disease (PD) in relation to the monoamine oxidase B intron 13 genetic polymorphism. A reduced PD risk related to pack-years of smoking was detected for persons with the G allele, whereas an opposite effect was found among persons with the A allele. These results indicate an unexplained interaction between cigarette smoking and this genetic polymorphism.
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页码：1458 / 1461
页数：4
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