A genetic polymorphism of MAO-B modifies the association of cigarette smoking and Parkinson's disease

被引：77

作者：

Checkoway, H

Franklin, GM

Costa-Mallen, P

Smith-Weller, T

Dilley, J

Swanson, PD

Costa, LG

机构：

[1] Univ Washington, Dept Environm Hlth, Seattle, WA 98195 USA

[2] Univ Washington, Dept Epidemiol, Seattle, WA 98195 USA

[3] Univ Washington, Dept Neurol, Seattle, WA 98195 USA

来源：

NEUROLOGY | 1998年 / 50卷 / 05期

关键词：

D O I：

10.1212/WNL.50.5.1458

中图分类号：

R74 [神经病学与精神病学];

学科分类号：

摘要：

In a population-based case-control study, we found a reversal of the association of cigarette smoking with Parkinson's disease (PD) in relation to the monoamine oxidase B intron 13 genetic polymorphism. A reduced PD risk related to pack-years of smoking was detected for persons with the G allele, whereas an opposite effect was found among persons with the A allele. These results indicate an unexplained interaction between cigarette smoking and this genetic polymorphism.

引用

页码：1458 / 1461

页数：4

共 8 条

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