Mitochondrial Trafficking and Processing of Telomerase RNA TERC

被引：69

作者：

Cheng, Ying ^{[1
]}

Liu, Peipei ^{[1
]}

Zheng, Qian ^{[1
]}

Gao, Ge ^{[1
]}

Yuan, Jiapei ^{[1
]}

Wang, Pengfeng ^{[2
]}

Huang, Jinliang ^{[1
]}

Xie, Leiming ^{[1
]}

Lu, Xinping ^{[1
]}

Tong, Tanjun ^{[2
,3
]}

Chen, Jun ^{[2
,3
]}

Lu, Zhi ^{[1
]}

Guan, Jisong ^{[1
]}

Wang, Geng ^{[1
]}

机构：

[1] Tsinghua Univ, Sch Life Sci, Cell Biol & Dev Ctr, MOE Key Lab Bioinformat, Beijing 100084, Peoples R China

[2] Peking Univ, Res Ctr Aging, Beijing 100191, Peoples R China

[3] Peking Univ, Dept Biochem & Mol Biol, Hlth Sci Ctr, Beijing 100191, Peoples R China

来源：

CELL REPORTS | 2018年 / 24卷 / 10期

关键词：

IMPORT; CANCER; DNA; DIFFERENTIATION; MUTATION; PNPT1; ENDS;

D O I：

10.1016/j.celrep.2018.08.003

中图分类号：

Q2 [细胞生物学];

学科分类号：

071009 ; 090102 ;

摘要：

Mitochondrial dysfunctions play major roles in many diseases. However, how mitochondrial stresses are relayed to downstream responses remains unclear. Here we show that the RNA component of mammalian telomerase TERC is imported into mitochondria, processed to a shorter form TERC-53, and then exported back to the cytosol. We found that the import is regulated by PNPASE, and the processing is controlled by mitochondrion-localized RNASET2. Cytosolic TERC-53 levels respond to changes in mitochondrial functions but have no direct effect on these functions. These findings uncover a mitochondrial RNA trafficking pathway and provide a potential mechanism for mitochondria to relay their functional states to other cellular compartments.

引用

页码：2589 / 2595

页数：7

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