Apoptotic neuronal death in Parkinson's disease: Involvement of nitric oxide

被引：109
作者：
Singh, Sarika
Dikshit, Madhu [1 ]
机构：
[1] Cent Drug Res Inst, Div Pharmacol, Lucknow 226001, Uttar Pradesh, India
[2] Cent Drug Res Inst, Div Toxicol, Lucknow 226001, Uttar Pradesh, India
来源：
BRAIN RESEARCH REVIEWS | 2007年 / 54卷 / 02期
关键词：
apoptosis; parkinson's disease; extrinsic pathway; intrinsic pathway; nitric oxide; peroxynitrite; mitochondria;
D O I：
10.1016/j.brainresrev.2007.02.001
中图分类号：
Q189 [神经科学];
学科分类号：
071006 ;
摘要：
Apoptosis of nigral dopaminergic neurons by various mechanisms is an emerging phenomenon involved in the degeneration of dopaminergic neurons in Parkinson's disease (PD). Both extrinsic and intrinsic pathways seems to be involved in death of nigral neurons, intrinsic pathway however, seems to be more important due to the energy crisis. Apoptosis by intrinsic pathway is executed by several initiators and effector caspases, which have been found activated in PD patients, experimental models as well as in neuronal cultures. Nitric oxide (NO) seems to be a central molecule due to its ability to modulate both pro and antiapoptotic phenomenon. The review focuses on the diverse extrinsic and intrinsic factors, signaling pathways and their modulation by NO leading to the death of dopaminergic neurons.
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收藏
页码：233 / 250
页数：18
相关论文
共 225 条
[31]   Molecular pathways involved in the neurotoxicity of 6-OHDA, dopamine and MPTP: contribution to the apoptotic theory in Parkinson's disease [J].
Blum, D ;
Torch, S ;
Lambeng, N ;
Nissou, MF ;
Benabid, AL ;
Sadoul, R ;
Verna, JM .
PROGRESS IN NEUROBIOLOGY, 2001, 65 (02) :135-172
[32]   p53 and Bax activation in 6-hydroxydopamine-induced apoptosis in PC12 cells [J].
Blum, D ;
Wu, Y ;
Nissou, MF ;
Arnaud, S ;
Benabid, AL ;
Verna, JM .
BRAIN RESEARCH, 1997, 751 (01) :139-142
[33]   INDUCTION OF NITRIC-OXIDE SYNTHASE IN DEMYELINATING REGIONS OF MULTIPLE-SCLEROSIS BRAINS [J].
BO, L ;
DAWSON, TM ;
WESSELINGH, S ;
MORK, S ;
CHOI, S ;
KONG, PA ;
HANLEY, D ;
TRAPP, BD .
ANNALS OF NEUROLOGY, 1994, 36 (05) :778-786
[34]   IMMUNOCYTOCHEMICAL ANALYSIS OF TUMOR-NECROSIS-FACTOR AND ITS RECEPTORS IN PARKINSONS-DISEASE [J].
BOKA, G ;
ANGLADE, P ;
WALLACH, D ;
JAVOYAGID, F ;
AGID, Y ;
HIRSCH, EC .
NEUROSCIENCE LETTERS, 1994, 172 (1-2) :151-154
[35]  
BOLANOS JP, 1995, J NEUROCHEM, V64, P1965
[36]   APOPTOSIS AND NECROSIS - 2 DISTINCT EVENTS INDUCED, RESPECTIVELY, BY MILD AND INTENSE INSULTS WITH N-METHYL-D-ASPARTATE OR NITRIC-OXIDE SUPEROXIDE IN CORTICAL CELL-CULTURES [J].
BONFOCO, E ;
KRAINC, D ;
ANKARCRONA, M ;
NICOTERA, P ;
LIPTON, SA .
PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA, 1995, 92 (16) :7162-7166
[37]   T-lymphocyte tumor necrosis factor-alpha receptor binding in patients with Parkinson's disease [J].
Bongioanni, P ;
Castagna, M ;
Maltinti, S ;
Boccardi, B ;
Dadone, F .
JOURNAL OF THE NEUROLOGICAL SCIENCES, 1997, 149 (01) :41-45
[38]   Molecular pathways to neurodegeneration [J].
Bossy-Wetzel, E ;
Schwarzenbacher, R ;
Lipton, SA .
NATURE MEDICINE, 2004, 10 (07) :S2-S9
[39]   Inhibition of mitochondrial respiratory complex I by nitric oxide, peroxynitrite and S-nitrosothiols [J].
Brown, GC ;
Borutaite, V .
BIOCHIMICA ET BIOPHYSICA ACTA-BIOENERGETICS, 2004, 1658 (1-2) :44-49
[40]  
CARRERAS CM, 2004, MOL ASPECTS MED, V25, P125
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