BIOCHEMICAL PARAMETERS OF DONOR PLATELET CONCENTRATES DURING THE STORAGE AFTER PATHOGEN INACTIVATION WITH THE AID OF TECHNOLOGY"AMOTOSALEN plus ULTRA-VIOLET A IRRADIATION"IN VITRO

被引：0

作者：

Azimova, M. Kh ^{[1
]}

Galstyan, G. M. ^{[1
]}

Gaponova, T., V ^{[1
]}

Karyakin, A., V ^{[1
]}

Kryukova, G. N. ^{[1
]}

Nekhaevskaya, S. S. ^{[1
]}

Skotselyas, E. D. ^{[1
]}

Flegontov, P. A. ^{[1
]}

机构：

[1] Natl Res Ctr Hematol, Moscow 125167, Russia

来源：

GEMATOLOGIYA I TRANSFUZIOLOGIYA | 2017年 / 62卷 / 01期

关键词：

platelet concentrate; reduction of pathogens; technology amotosalen plus UVA; incremental solution SSP; pH; glucose; lactate; citrate; P-selectin; antigen CD62P(+); IN-VITRO; ADDITIVE SOLUTION;

D O I：

10.18821/0234-5730-2017-62-1-37-40

中图分类号：

R5 [内科学];

学科分类号：

1002 ; 100201 ;

摘要：

Pathogen inactivation (PI) treatment of platelet concentrates (PCs) improves the transfusion safety. PI technology allows to store of PCs up to 7 days. The usage of platelet additive solution (PAS) reduces the risk of non-hemolytic transfusion reactions and enhances platelet quality during storage. The influence of the combinations of PI and PAS and PI and 100% plasma on the biochemical parameters of PCs remained unclear. The aim of the study was to analyze the impact PI technology on the biochemical parameters and functional activity of platelets suspended in 100% plasma or 70% PAS and 30% plasma. The pathogens reduction does not influence on the glucose consumption and citrate content, accelerates the accumulation of lactate and lowers the pH of the medium storage donor platelet concentrates. In the samples with additive solution SSP+ changes of biochemical parameters were expressed to a lesser degree.

引用

页码：37 / 40

页数：4