Cancer- and non-cancer related chronic pain: from the physiopathological basics to management

被引：29

作者：

Sica, Antonello ^{[1
]}

Casale, Beniamino ^{[2
]}

Di Dato, Maria Teresa ^{[3
]}

Calogero, Armando ^{[4
]}

Spada, Alessandro ^{[1
]}

Sagnelli, Caterina ^{[5
]}

Santagata, Mario ^{[6
]}

Buonavolonta, Pietro ^{[3
]}

Fiorelli, Alfonso ^{[7
]}

Salzano, Anna ^{[3
]}

Dodaro, Concetta Anna ^{[4
]}

Martinelli, Erika ^{[1
]}

Saracco, Elisabetta ^{[3
]}

Troiani, Teresa ^{[1
]}

Tammaro, Dario ^{[3
]}

Ciardiello, Fortunato ^{[1
]}

Papa, Alfonso ^{[3
]}

机构：

[1] Univ Campania Luigi Vanvitelli, Dept Precis Med, Naples, Italy

[2] AO Colli V Monaldi, Dept Pneumol & Tisiot, Naples, Italy

[3] AO Colli V Monaldi, Pain Dept, Naples, Italy

[4] Univ Naples Federico II, Dept Adv Biomed Sci, Naples, Italy

[5] Univ Campania Luigi Vanvitelli, Dept Mental Hlth & Publ Med, Naples, Italy

[6] Univ Campania Luigi Vanvitelli, Multidisciplinary Dept Med Surg & Dent Specialtie, Naples, Italy

[7] Univ Campania Luigi Vanvitelli, Thorac Surg Unit, Naples, Italy

来源：

OPEN MEDICINE | 2019年 / 14卷 / 01期

关键词：

Pain; Chronic pain; Non-cancer pain; Cancer pain; Intrathecal therapy; chronic pain therapy; INTRATHECAL DRUG-DELIVERY; CONFERENCE PACC RECOMMENDATIONS; NEUROPATHIC PAIN; DIFFERENTIAL EXPRESSION; VIRUS-INFECTION; IMMUNE CELLS; OPEN-LABEL; ZICONOTIDE; CYTOKINES; BUPIVACAINE;

D O I：

10.1515/med-2019-0088

中图分类号：

R5 [内科学];

学科分类号：

1002 ; 100201 ;

摘要：

The prevalence of chronic pain is between 33% to 64% and is due to cancer pain, but it has also been observed in non-cancer patients. Chronic pain is associated with lower quality of life and higher psychological distress and depressive/anxiety disorders in patients without a history of disorder. In this study we evaluated in clinical practice the effectiveness of the intrathecal pump in 140 patients who underwent pain therapy at our Center. These patients were consecutively enrolled from January 2010 to July 2018. Follow-up was carried out over these eight years regarding the infusion modalities. Pain relief was obtained in 71 (50,7%) patients out of the 140 that experienced satisfactory pain control globally. Intrathecal therapy is one of the best options for chronic severe refractory pain. The greatest advantage of this therapy is due to the possibility of treating the pain with minimal dosages of the drug, avoiding the appearance of troublesome side effects.

引用

页码：761 / 766

页数：6

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