Addition of neuA, the gene encoding N-acylneuraminate cytidylyl transferase, increases the discriminatory ability of the consensus sequence-based scheme for typing Legionella pneumophila serogroup 1 strains

被引：218

作者：

Ratzow, Sandra

Gaia, Valeria

Helbig, Juergen Herbert

Fry, Norman K.

Lueck, Paul Christian

机构：

[1] Tech Univ Dresden, Inst Med Mikrobiol & Hyg, D-01307 Dresden, Germany

[2] Inst Cantonale Microbiol, Lugano, Switzerland

[3] Hlth Protect Agcy, Ctr Infect, Resp & Syst Infect Lab, London, England

来源：

JOURNAL OF CLINICAL MICROBIOLOGY | 2007年 / 45卷 / 06期

关键词：

D O I：

10.1128/JCM.00261-07

中图分类号：

Q93 [微生物学];

学科分类号：

071005 ; 100705 ;

摘要：

The standard sequence-based method for the typing of Legionella pneumophila serogroup I strains was extended by using the gspA and neuA alleles. The use of neuA as a seventh allele for typing significantly increased the index of discrimination calculated for a panel of unrelated strains (from 0.932 to 0.963) and subdivided some known large common complexes (e.g., 1,4,3,1,1,1). This modification to the standard method is proposed as the method of choice in the epidemiological investigation of L. pneumophila infections.

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页码：1965 / 1968

页数：4

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