Circadian expression of serotonin N-acetyltransferase mRNA in the rat retina

被引：59

作者：

Sakamoto, K ^{[1
]}

Ishida, N ^{[1
]}

机构：

[1] Minist Int Trade & Ind, Agcy Ind Sci & Technol, Natl Inst Biosci & Human Technol, Ishida Grp Clock Gene, Tsukuba, Ibaraki 305, Japan

来源：

NEUROSCIENCE LETTERS | 1998年 / 245卷 / 02期

关键词：

circadian rhythm; arylalkylamine N-acetyltransferase; melatonin; retina; mammals; rat;

D O I：

10.1016/S0304-3940(98)00189-X

中图分类号：

Q189 [神经科学];

学科分类号：

071006 ;

摘要：

To investigate the molecular mechanism of the melatonin rhythm in the mammalian retina, we examined the temporal mRNA expression pattern of serotonin N-acetyltransferase (arylalkylamine N-acetyltransferase, AA-NAT; the rate-limiting enzyme in melatonin synthesis) in the rat retina. Northern blot analysis showed that in a daily light-dark cycle retinal AA-NAT mRNA was low during the day and increased more than threefold at night, and this daily rhythm persisted even in constant darkness. These findings suggest that AA-NAT mRNA expression in the rat retina is regulated by an endogenous circadian clock. (C) 1998 Elsevier Science Ireland Ltd.

引用

页码：113 / 116

页数：4

共 20 条

[1]

Arendt J., 1995, MELATONIN MAMMALIAN

[2] PINEAL-GLAND - NEUROCHEMICAL TRANSDUCER [J].