Gut microbiome in gastrointestinal cancer: a friend or foe?

被引：51

作者：

Liu, Yang ^{[1
]}

Baba, Yoshifumi ^{[2
,3
]}

Ishimoto, Takatsugu ^{[2
,4
]}

Gu, Xi

Zhang, Jun ^{[2
,4
]}

Nomoto, Daichi ^{[2
]}

Okadome ^{[2
]}

Baba, Hideo ^{[2
,5
]}

Qiu, Peng ^{[6
]}

机构：

[1] China Med Univ, Dept Oncol, Shengjing Hosp, Shenyang 110004, Liaoning, Peoples R China

[2] Kumamoto Univ, Grad Sch Med Sci, Dept Surg Gastroenterol, Kumamoto, Japan

[3] Kumamoto Univ, Grad Sch Med Sci, Dept Next Generat Surg Therapy Dev, Kumamoto, Japan

[4] Kumamoto Univ, Int Res Ctr Med Sci, Gastrointestinal Canc Biol, Kumamoto, Japan

[5] Kumamoto Univ, Ctr Metab Regulat Hlth Aging, Kumamoto, Japan

[6] China Med Univ, Dept Anesthesiol, Shengjing Hosp, Shenyang 110004, Liaoning, Peoples R China

来源：

INTERNATIONAL JOURNAL OF BIOLOGICAL SCIENCES | 2022年 / 18卷 / 10期

基金：

中国国家自然科学基金;

关键词：

gut microbiota; GI cancer; carcinogenesis; chemotherapy; CHAIN FATTY-ACIDS; FUSOBACTERIUM-NUCLEATUM; HELICOBACTER-PYLORI; INTESTINAL MICROBIOTA; PANCREATIC-CANCER; ANTITUMOR IMMUNITY; COLORECTAL-CANCER; PROMOTES; CELLS; DYSBIOSIS;

D O I：

10.7150/ijbs.69331

中图分类号：

Q5 [生物化学]; Q7 [分子生物学];

学科分类号：

071010 ; 081704 ;

摘要：

The impact of the gut microbiome on host health is becoming increasingly recognized. To date, there is growing evidence that the complex characteristics of the microbial community play key roles as potential biomarkers and predictors of responses in cancer therapy. Many studies have shown that altered commensal bacteria lead to cancer susceptibility and progression in diverse pathways. In this review, we critically assess the data for gut microbiota related to gastrointestinal cancer, including esophageal, gastric, pancreatic, colorectal cancer, hepatocellular carcinoma and cholangiocarcinoma. Importantly, the underlying mechanisms of gut microbiota involved in cancer occurrence, prevention and treatment are elucidated. The purpose of this review is to provide novel insights for applying this understanding to the development of new therapeutic strategies in gastrointestinal cancer by targeting the microbial community.

引用

页码：4101 / 4117

页数：17

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