Sexual dimorphism in cancer

被引：266

作者：

Clocchiatti, Andrea ^{[1
]}

Cora, Elisa ^{[2
]}

Zhang, Yosra ^{[1
,2
]}

Dotto, G. Paolo ^{[1
,2
]}

机构：

[1] Massachusetts Gen Hosp, Cutaneous Biol Res Ctr, Charlestown, MA 02129 USA

[2] Univ Lausanne, Dept Biochem, CH-1066 Epalinges, Switzerland

来源：

NATURE REVIEWS CANCER | 2016年 / 16卷 / 05期

基金：

美国国家卫生研究院; 瑞士国家科学基金会; 欧洲研究理事会;

关键词：

ESTROGEN-RECEPTOR-BETA; CHRONIC MYELOID-LEUKEMIA; Y-CHROMOSOME GENES; ANDROGEN RECEPTOR; PROSTATE-CANCER; BREAST-CANCER; TUMOR-SUPPRESSOR; GROWTH-HORMONE; HEPATOCELLULAR-CARCINOMA; CELL-PROLIFERATION;

D O I：

10.1038/nrc.2016.30

中图分类号：

R73 [肿瘤学];

学科分类号：

100214 ;

摘要：

The incidence of many types of cancer arising in organs with non-reproductive functions is significantly higher in male populations than in female populations, with associated differences in survival. Occupational and/or behavioural factors are well-known underlying determinants. However, cellular and molecular differences between the two sexes are also likely to be important. In this Opinion article, we focus on the complex interplay that sex hormones and sex chromosomes can have in intrinsic control of cancer-initiating cell populations, the tumour microenvironment and systemic determinants of cancer development, such as the immune system and metabolism. A better appreciation of these differences between the two sexes could be of substantial value for cancer prevention as well as treatment.

引用

页码：330 / 339

页数：10

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