Lateral hypothalamic acetylcholinesterase-immunoreactive neurons co-express either orexin or melanin concentrating hormone

被引：10

作者：

Chou, TC

Rotman, SR

Saper, CB ^{[1
]}

机构：

[1] Harvard Univ, Beth Israel Deaconess Med Ctr, Sch Med, Dept Neurol, Boston, MA 02215 USA

[2] Harvard Univ, Beth Israel Deaconess Med Ctr, Sch Med, Program Neurosci, Boston, MA 02215 USA

来源：

NEUROSCIENCE LETTERS | 2004年 / 370卷 / 2-3期

关键词：

acetylcholinesterase; orexin; melanin-concentrating hormone; hypothalamus; cortex;

D O I：

10.1016/j.neulet.2004.08.070

中图分类号：

Q189 [神经科学];

学科分类号：

071006 ;

摘要：

The lateral hypothalamic area (LHA) contains a large population of neurons that express the enzyme acetylcholinesterase (ACNE), but are not themselves cholinergic. Some of these neurons have been shown to contain melanin-concentrating hormone (MCH), a neuropeptide implicated in regulating feeding, but the identities of the remaining neurons are unknown. We now report that nearly all ACNE-immunoreactive neurons in the LHA express immunoreactivity for either MCH or for orexin, a peptide implicated in regulating wakefulness. Furthermore, most orexin neurons and MCH neurons appear to contain ACNE. ACNE immunoreactivity appears to be a key feature of nearly all of the diffusely-projecting cortical systems. (C) 2004 Elsevier Ireland Ltd. All rights reserved.

引用

页码：123 / 126

页数：4

共 24 条

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