First synthesis and pharmacological evaluation of benzoindolizidine and benzoquinolizidine analogues of α- and β-peltatin

被引：17

作者：

Couture, A ^{[1
]}

Deniau, E

Grandclaudon, P

Lebrun, S

Léonce, S

Renard, P

Pfeiffer, B

机构：

[1] Univ Sci & Technol Lille, CNRS, ESA 8009, Chim Organ Phys Lab, F-59655 Villeneuve Dascq, France

[2] Inst Rech Int Servier, Div Cancerol Expt, F-92415 Suresnes, France

[3] ADIR, F-92415 Courbevoie, France

来源：

BIOORGANIC & MEDICINAL CHEMISTRY | 2000年 / 8卷 / 08期

关键词：

D O I：

10.1016/S0968-0896(00)00130-9

中图分类号：

Q5 [生物化学]; Q7 [分子生物学];

学科分类号：

071010 ; 081704 ;

摘要：

The benzoindolizidine and-quinolizidine analogues of alpha- and beta-peltatin were designed and synthesized by two different synthetic routes involving as the key step the Bischler-Napieralski cyclization of suitably substituted N-acyl-2-arylmethylpyrrolidine and -piperidine derivatives. The in vitro biological activity of these analogues as well as some of their derivatives was subsequently evaluated. (C) 2000 Elsevier Science Ltd. All rights reserved.

引用

页码：2113 / 2125

页数：13

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