MicroRNAs, long noncoding RNAs, and circular RNAs: potential tumor biomarkers and targets for colorectal cancer

被引：81

作者：

Yang, Shuaixi ^{[1
]}

Sun, Zhenqiang ^{[1
]}

Zhou, Quanbo ^{[1
]}

Wang, Weiwei ^{[2
,3
]}

Wang, Guixian ^{[1
]}

Song, Junmin ^{[1
]}

Li, Zhen ^{[1
]}

Zhang, Zhiyong ^{[1
]}

Chang, Yuan ^{[1
]}

Xia, Kunkun ^{[1
]}

Liu, Jinbo ^{[1
]}

Yuan, Weitang ^{[1
]}

机构：

[1] Zhengzhou Univ, Dept Colorectal Surg, Affiliated Hosp 1, Zhengzhou 450052, Henan, Peoples R China

[2] Zhengzhou Univ, Dept Pathol, Affiliated Hosp 1, Zhengzhou 450001, Henan, Peoples R China

[3] Zhengzhou Univ, Sch Basic Med, Dept Pathol, Zhengzhou 450002, Henan, Peoples R China

来源：

CANCER MANAGEMENT AND RESEARCH | 2018年 / 10卷

基金：

中国国家自然科学基金; 中国博士后科学基金;

关键词：

biomarker; competitive endogenous RNA; tumorigenesis; epithelial-to-mesenchymal transition; invasion; metastasis; chemoresistance; COLON-CANCER; CELL-PROLIFERATION; MESENCHYMAL TRANSITION; STEM-CELLS; PROMOTES; METASTASIS; PROGRESSION; EXPRESSION; BINDING; GROWTH;

D O I：

10.2147/CMAR.S166308

中图分类号：

R73 [肿瘤学];

学科分类号：

100214 ;

摘要：

Noncoding RNAs (ncRNAs) can be divided into microRNAs (miRNAs), long noncoding RNAs (lncRNAs), circular RNAs (circRNAs), pRNAs, and tRNAs. Traditionally, miRNAs exert their biological function mainly through the inhibition of translation via the induction of target RNA transcript degradation. lncRNAs and circRNAs were once considered to have no potential to code proteins. Here, we will review the current knowledge on ncRNAs in relation to their origins, characteristics, and functions. We will also review how ncRNAs work as competitive endogenous RNA, gene transcription and expression regulators, and RNA-binding protein sponges in colorectal cancer (CRC). Notably, except for the abovementioned mechanisms, recent advances revealed that lncRNAs can also act as the precursor of miRNAs, and a small portion of lncRNAs and circRNAs was verified to have the potential to code proteins, providing new evidence for the significance of ncRNAs in CRC tumorigenesis and development.

引用

页码：2249 / 2257

页数：9

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