Estrogen receptors in the brain-pituitary complex and the neuroendocrine regulation of gonadotropin release in rainbow trout

被引：37

作者：

Kah, O ^{[1
]}

Anglade, I ^{[1
]}

Linard, B ^{[1
]}

Pakdel, F ^{[1
]}

Salbert, G ^{[1
]}

Bailhache, T ^{[1
]}

Ducouret, B ^{[1
]}

Saligaut, C ^{[1
]}

Le Goff, P ^{[1
]}

Valotaire, Y ^{[1
]}

Jego, P ^{[1
]}

机构：

[1] INRA, Inst Rennais Biol & Ecol Poissons, URA CNRS 256, Equipe Endocrinol Mol Reprod, F-35042 Rennes, France

来源：

FISH PHYSIOLOGY AND BIOCHEMISTRY | 1997年 / 17卷 / 1-6期

关键词：

estrogen receptor; estradiol; gonadotropin-releasing hormone; tyrosine hydroxylase; gonadotropin; hypothalamus; pituitary; neuroendocrine control of reproduction; salmonid; teleost fish;

D O I：

10.1023/A:1007749715473

中图分类号：

Q5 [生物化学]; Q7 [分子生物学];

学科分类号：

071010 ; 081704 ;

摘要：

In all vertebrates, steroid feedback is one of the mechanisms by which the brain is constantly kept informed on the physiological status of the periphery. It is, therefore, a very efficient system of synchronization between the different actors of the brain-pituitary-effector axis, particularly in the context of reproduction. The central effects of steroids are mediated by specific receptors belonging to the superfamily of intracellular receptors and acting as ligand dependant transcription factors to modulate the expression of certain target genes. In order to investigate the molecular events underlying steroid actions in the brain/pituitary complex, it is necessary, as a first step, to locate precisely steroid expressing cells in the brain/pituitary complex and to identify the phenotype of these cells on the basis of the neurohormone(s) or hormones they produce. This paper will review recent data obtained in our laboratory regarding the distribution and regulation of expression of estrogen receptors in the brain and pituitary gland of the rainbow trout (Oncorhynchus mykiss), using both in situ hybridization or immunohistochemistry. In addition, information concerning the phenotypic identification of cells expressing these receptors is presented, especially with respect to the main neuroendocrine systems controlling reproduction. The functional meaning of these data are discussed in the context of the reproductive physiology of trout.

引用

页码：53 / 62

页数：10

共 40 条

[1] ACTIVATION OF SALMON GONADOTROPIN-RELEASING-HORMONE SYNTHESIS BY 17-ALPHA-METHYLTESTOSTERONE ADMINISTRATION IN YEARLING MASU SALMON, ONCORHYNCHUS-MASOU [J].