Interaction of Mycobacterium tuberculosis with Host Cell Death Pathways

被引：64

作者：

Srinivasan, Lalitha ^{[1
]}

Ahlbrand, Sarah ^{[1
]}

Briken, Volker ^{[1
]}

机构：

[1] Univ Maryland, Dept Cell Biol & Mol Genet, College Pk, MD 20742 USA

来源：

COLD SPRING HARBOR PERSPECTIVES IN MEDICINE | 2014年 / 4卷 / 08期

基金：

美国国家卫生研究院;

关键词：

BACILLUS-CALMETTE-GUERIN; INNATE IMMUNITY; INFECTED MACROPHAGES; APOPTOTIC VESICLES; NLRP3; INFLAMMASOME; ADAPTIVE IMMUNITY; SECRETION SYSTEMS; VII SECRETION; PROTEIN; ACTIVATION;

D O I：

10.1101/cshperspect.a022459

中图分类号：

R-3 [医学研究方法]; R3 [基础医学];

学科分类号：

1001 ;

摘要：

Mycobacterium tuberculosis (Mtb) has coevolved with humans for tens of thousands of years. It is thus highly adapted to its human host and has evolved multiple mechanisms to manipulate host immune responses to its advantage. One central host pathogen interaction modality is host cell death pathways. Host cell apoptosis is associated with a protective response to Mtb infection, whereas a necrotic response favors the pathogen. Consistently, Mtb inhibits host cell apoptosis signaling but promotes induction of programmed necrosis. The molecular mechanisms involved in Mtb-mediated host cell death manipulation, the consequences for host immunity, and the potential for therapeutic and preventive approaches will be discussed.

引用

页数：15

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