Interleukin-6 (IL-6) and soluble forms of IL-6 receptors are not altered in cerebrospinal fluid of Alzheimer's disease patients

被引：55
作者：
März, P
Heese, K
Hock, C
Golombowski, S
Müller-Spahn, F
Rose-John, S
Otten, U
机构：
[1] Univ Basel, Dept Physiol, CH-4051 Basel, Switzerland
[2] Univ Mainz, Div Pathophysiol, Dept Med, D-55101 Mainz, Germany
[3] Univ Basel, Dept Psychiat, CH-4025 Basel, Switzerland
来源：
NEUROSCIENCE LETTERS | 1997年 / 239卷 / 01期
关键词：
cytokines; neurodegeneration; neurotrophins; inflammation; enzyme-linked immunosorbent assay;
D O I：
10.1016/S0304-3940(97)00886-0
中图分类号：
Q189 [神经科学];
学科分类号：
071006 ;
摘要：
We quantitated interleukin-6 (IL-6), soluble IL-6 receptor (sIL-6R) and soluble form of the IL-6 signal-transducing protein gp130 (sgp130) in cerebrospinal fluid (CSF) of patients with Alzheimer's disease (AD) (n = 17) and control subjects (n = 18) using sensitive enzyme-linked immunosorbent assays (ELISA). Our results show that none of the parameters examined was significantly different in CSF of AD patients as compared to control age-matched non-demented patients. We conclude that CSF levels of IL-6 and their soluble receptors do not necessarily reflect local changes of the IL-6 system that has been shown to be involved in neurodegenerative events occurring in AD. Levels of sgp130 are substantially high (approximately 100 ng/ml) in the CSF of all individuals probably representing a high antagonistic potential. (C) 1997 Elsevier Science Ireland Ltd.
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收藏
页码：29 / 32
页数：4
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