Vaginal yolk sac (endodermal sinus) tumors in infancy presenting persistent vaginal bleeding

被引：13

作者：

Watanabe, Noriko ^{[1
]}

Okita, Hajime ^{[4
]}

Matsuoka, Kentaro

Kiyotani, Chikako ^{[3
]}

Fujii, Eriko ^{[2
]}

Kumagai, Masaaki ^{[3
]}

Nakagawa, Atsuko

机构：

[1] Natl Ctr Child Hlth & Dev, Div Pathol, Setagaya Ku, Tokyo 1578535, Japan

[2] Natl Ctr Child Hlth & Dev, Div Gynecol Womens Hlth, Tokyo 1578535, Japan

[3] Natl Ctr Child Hlth & Dev, Div Hematol Oncol, Tokyo 1578535, Japan

[4] Natl Res Inst Child Hlth & Dev, Dept Dev Biol, Tokyo, Japan

来源：

JOURNAL OF OBSTETRICS AND GYNAECOLOGY RESEARCH | 2010年 / 36卷 / 01期

关键词：

abnormal uterine bleeding; cancer of the vagina; chemotherapy in GYN cancers; pediatric gynecology; pediatrics; GERM-CELL TUMORS; SURGERY; CHEMOTHERAPY; CARCINOMA; CHILDREN; THERAPY; VULVA;

D O I：

10.1111/j.1447-0756.2009.01083.x

中图分类号：

R71 [妇产科学];

学科分类号：

100211 ;

摘要：

Vaginal yolk sac (endodermal sinus) tumors were diagnosed in two girls (ages 12 and 46 months). In both, the only manifestation was persistent vaginal bleeding. Pelvic ultrasonography, computed tomography, and magnetic resonance imaging revealed solitary vaginal masses (diameter, 5 and 2 cm, respectively). Serum alpha-fetoprotein was highly elevated in one patient and normal in the other. Biopsy was performed in the first patient, and a tumor excision, in the second. Combination chemotherapy with cisplatin, etoposide, and bleomycin or carboplatin was administered to the first patient, and shortly thereafter, the tumor size decreased by more than half; serum alpha-fetoprotein was normalized after four chemotherapy cycles. After chemotherapy, magnetic resonance imaging revealed a small residual lesion, however the second biopsy revealed no viable tumor cells. In the second patient, no visible tumor was observed after chemotherapy by vaginoscopy. Both patients are well at 19 and 14 months after diagnosis, respectively.

引用

页码：213 / 216

页数：4