iPSCs-based anti-aging therapies: Recent discoveries and future challenges

被引：5

作者：

Pareja-Galeano, Helios ^{[1
,2
]}

Sanchis-Gomar, Fabian ^{[2
]}

Perez, Laura M. ^{[3
]}

Emanuele, Enzo ^{[4
]}

Lucia, Alejandro ^{[1
,2
]}

Galvez, Beatriz G. ^{[1
,3
]}

Esther Gallardo, Maria ^{[2
,5
,6
,7
]}

机构：

[1] European Univ Madrid, C Tajo S-N, Madrid 28670, Spain

[2] Hosp 12 Octubre I 12, Res Inst, Madrid, Spain

[3] CNIC, Madrid, Spain

[4] 2E Sci, Robbio, PV, Italy

[5] Univ Autonoma Madrid, Fac Med, Dept Bioquim, Madrid, Spain

[6] UAM, CSIC, Inst Invest Biomed Alberto Sols, Madrid, Spain

[7] Ctr Invest Biomed Red CIBERER, Valencia, Spain

来源：

AGEING RESEARCH REVIEWS | 2016年 / 27卷

关键词：

Induced pluripotent stem cells; Regenerative medicine; Sarcopenia; In vivo reprogramming; DOT1L; PLURIPOTENT STEM-CELLS; HUMAN FIBROBLASTS; SENESCENCE; CONVERSION; TARGETS; SET;

D O I：

10.1016/j.arr.2016.02.007

中图分类号：

Q2 [细胞生物学];

学科分类号：

071009 ; 090102 ;

摘要：

The main biological hallmarks of the aging process include stem cell exhaustion and cellular senescence. Consequently, research efforts to treat age-related diseases as well as anti-aging therapies in general have recently focused on potential 'reprogramming' regenerative therapies. These new approaches are based on induced pluripotent stem cells (iPSCs), including potential in vivo reprogramming for tissue repair. Another possibility is targeting pathways of cellular senescence, e.g., through modulation of p16INK4a signaling and especially inhibition of the nuclear factor kappa-light-chain-enhancer of activated B cells (NF-kappa B). Here, we reviewed and discussed these recent developments together with their possible usefulness for future treatments against sarcopenia, a major age-related condition. (C) 2016 Elsevier B.V. All rights reserved.

引用

页码：37 / 41

页数：5

共 46 条

[41] Induction of pluripotent stem cells from adult human fibroblasts by defined factors
Takahashi, Kazutoshi
Tanabe, Koji
Ohnuki, Mari
Narita, Megumi
Ichisaka, Tomoko
Tomoda, Kiichiro
Yamanaka, Shinya
[J]. CELL, 2007, 131 (05) : 861 - 872
[42] Direct Conversion of Fibroblasts into Stably Expandable Neural Stem Cells
Thier, Marc
Woersdoerfer, Philipp
Lakes, Yenal B.
Gorris, Raphaela
Herms, Stefan
Opitz, Thoralf
Seiferling, Dominic
Quandel, Tamara
Hoffmann, Per
Noethen, Markus M.
Bruestle, Oliver
Edenhofer, Frank
[J]. CELL STEM CELL, 2012, 10 (04) : 473 - 479
[43] Waite LJ, 2004, POPUL DEV REV, V30, P3
[44] Reprogramming efficiency and quality of induced Pluripotent Stem Cell (iPSCs) generated from muscle-derived fibroblasts of mdx mice at different ages
Wang, Bo
Miyagoe-Suzuki, Yuko
Yada, Erica
Ito, Naoki
Nishiyama, Takashi
Nakamura, Miho
Ono, Yusuke
Motohashi, Norio
Segawa, Makoto
Masuda, Satoru
Takeda, Shin'ichi
[J]. PLOS CURRENTS-TREE OF LIFE, 2011,
[45] Induced Pluripotent Stem Cells
Wilson, Kitchener D.
Wu, Joseph C.
[J]. JAMA-JOURNAL OF THE AMERICAN MEDICAL ASSOCIATION, 2015, 313 (16): : 1613 - 1614
[46] Establishment of Induced Pluripotent Stem Cells from Centenarians for Neurodegenerative Disease Research
Yagi, Takuya
Kosakai, Arifumi
Ito, Daisuke
Okada, Yohei
Akamatsu, Wado
Nihei, Yoshihiro
Nabetani, Akira
Ishikawa, Fuyuki
Arai, Yasumichi
Hirose, Nobuyoshi
Okano, Hideyuki
Suzuki, Norihiro
[J]. PLOS ONE, 2012, 7 (07):

← 1 2 3 4 5 →