iPSCs-based anti-aging therapies: Recent discoveries and future challenges

被引：5
作者：
Pareja-Galeano, Helios [1 ,2 ]
Sanchis-Gomar, Fabian [2 ]
Perez, Laura M. [3 ]
Emanuele, Enzo [4 ]
Lucia, Alejandro [1 ,2 ]
Galvez, Beatriz G. [1 ,3 ]
Esther Gallardo, Maria [2 ,5 ,6 ,7 ]
机构：
[1] European Univ Madrid, C Tajo S-N, Madrid 28670, Spain
[2] Hosp 12 Octubre I 12, Res Inst, Madrid, Spain
[3] CNIC, Madrid, Spain
[4] 2E Sci, Robbio, PV, Italy
[5] Univ Autonoma Madrid, Fac Med, Dept Bioquim, Madrid, Spain
[6] UAM, CSIC, Inst Invest Biomed Alberto Sols, Madrid, Spain
[7] Ctr Invest Biomed Red CIBERER, Valencia, Spain
来源：
AGEING RESEARCH REVIEWS | 2016年 / 27卷
关键词：
Induced pluripotent stem cells; Regenerative medicine; Sarcopenia; In vivo reprogramming; DOT1L; PLURIPOTENT STEM-CELLS; HUMAN FIBROBLASTS; SENESCENCE; CONVERSION; TARGETS; SET;
D O I：
10.1016/j.arr.2016.02.007
中图分类号：
Q2 [细胞生物学];
学科分类号：
071009 ; 090102 ;
摘要：
The main biological hallmarks of the aging process include stem cell exhaustion and cellular senescence. Consequently, research efforts to treat age-related diseases as well as anti-aging therapies in general have recently focused on potential 'reprogramming' regenerative therapies. These new approaches are based on induced pluripotent stem cells (iPSCs), including potential in vivo reprogramming for tissue repair. Another possibility is targeting pathways of cellular senescence, e.g., through modulation of p16INK4a signaling and especially inhibition of the nuclear factor kappa-light-chain-enhancer of activated B cells (NF-kappa B). Here, we reviewed and discussed these recent developments together with their possible usefulness for future treatments against sarcopenia, a major age-related condition. (C) 2016 Elsevier B.V. All rights reserved.
引用
收藏
页码：37 / 41
页数：5
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