Review Bcl6-Mediated Transcriptional Regulation of Follicular Helper T cells (TFH)

被引：130

作者：

Choi, Jinyong ^{[1
,2
]}

Crotty, Shane ^{[1
,3
]}

机构：

[1] La Jolla Inst Immunol LJI, Ctr Infect Dis & Vaccine Res, La Jolla, CA 92037 USA

[2] Catholic Univ Korea, Dept Microbiol, Coll Med, Seoul, South Korea

[3] Univ Calif San Diego, Div Infect Dis & Global Publ Hlth, Dept Med, La Jolla, CA 92093 USA

来源：

TRENDS IN IMMUNOLOGY | 2021年 / 42卷 / 04期

基金：

美国国家卫生研究院;

关键词：

Bcl6; cell differentiation; follicular helper T cells; gene expression; germinal center; transcription factors;

D O I：

10.1016/j.it.2021.02.002

中图分类号：

R392 [医学免疫学]; Q939.91 [免疫学];

学科分类号：

100102 ;

摘要：

Follicular helper T cells (TFH) are essential B cell-help providers in the formation of germinal centers (GCs), affinity maturation of GC B cells, differentiation of high-affinity antibody-producing plasma cells, and production of memory B cells. The transcription factor (TF) B cell lymphoma 6 (Bcl6) is at the center of gene regulation in TFH biology, including differentiation and function, but how Bcl6 does this, and what additional TFs contribute, remain complex questions. This review focuses on advances in our understanding of Bcl6-mediated gene regulation of TFH functions, and the modulation of TFH by other TFs. These advances may have important implications in deciphering how repressor TFs can regulate many immunological cell types. An improved understanding of TFH biology will likely provide insights into biomedically relevant diseases.

引用

页码：336 / 349

页数：14

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