Cyclic recovery of adenovirus in a stem cell transplant recipient: an inverse association with graft-versus-host disease

被引:5
作者
Echavarria, M
Herrera, F
Solimano, J
Villamea, L
Riera, L
de Klerk, EPA
Kroes, ACM
Carballal, G
机构
[1] CEMIC, Div Virol, RA-1431 Buenos Aires, DF, Argentina
[2] CEMIC, Infectol Div, RA-1431 Buenos Aires 4102, DF, Argentina
[3] CEMIC, Div Hematol, RA-1431 Buenos Aires 4102, DF, Argentina
[4] Leiden Univ, Med Ctr, Dept Med Microbiol, Leiden, Netherlands
关键词
adenovirus; stem cell transplantation; hemorrhagic cystitis; graft-versus-host disease; cyclic recovery;
D O I
10.1038/sj.bmt.1703814
中图分类号
Q6 [生物物理学];
学科分类号
071011 ;
摘要
Adenovirus (AdV) infections have been increasingly recognized as significant pathogens that may cause severe morbidity and mortality among stem cell transplant (SCT) recipients. AdV can cause localized infections such as hemorrhagic cystitis (HC), pneumonia, hepatitis and also disseminated disease that can lead to death. We report a case of severe hemorrhagic cystitis in a SCT recipient who died 83 days after transplant. In this patient, AdV recovery was not constantly detected. In fact, fluctuations of the AdV detection in leukocytes and urine were observed by culture and PCR. When analyzing this viral cyclic recovery with different signs or symptoms in the patient, we observed an inverse association with the presence of acute graft-versus-host disease (GVHD). Whether these fluctuations represent donor-derived reactivity, indirectly manifested by the presence of GVHD, requires further study. This is the first case describing a dynamic pattern of AdV replication in leukocytes and urine samples from a patient with severe HC and the temporal correlation with GVHD.
引用
收藏
页码:301 / 303
页数:3
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