Clinicopathological Study of 13 Cases of Squamous Cell Carcinoma Complicating Hidradenitis Suppurativa

被引：86

作者：

Lavogiez, C. ^{[2
]}

Delaporte, E. ^{[2
]}

Darras-Vercambre, S. ^{[2
]}

De Lassalle, E. Martin ^{[3
]}

Castillo, C. ^{[3
]}

Mirabel, X. ^{[5
]}

Laurent, F. ^{[4
]}

Patenotre, P. ^{[4
]}

Gheit, T. ^{[6
]}

Talmant, J. C. ^{[7
]}

Beylot-Barry, M. ^{[8
]}

Martinot, V. ^{[4
]}

Piette, F. ^{[2
]}

Aubin, F. ^{[9
]}

Mortier, L. ^{[1
,2
]}

机构：

[1] CHRU, Hop Claude Huriez, Dermatol Clin, FR-59037 Lille, France

[2] Univ Lille 2, Lille, France

[3] CHRU, Serv Anat Pathol, FR-59037 Lille, France

[4] CHRU, Serv Chirurg Plast & Reparatrice, FR-59037 Lille, France

[5] Ctr Oscar Lambret, Serv Radiotherapie, F-59020 Lille, France

[6] Int Agcy Res Canc, F-69372 Lyon, France

[7] CHU Strasbourg, Serv Chirurg Plast & Reparatrice, F-67000 Strasbourg, France

[8] CHU Bordeaux, Serv Dermatol, Bordeaux, France

[9] Univ Franche Comte, CHU Besancon, F-25030 Besancon, France

来源：

DERMATOLOGY | 2010年 / 220卷 / 02期

关键词：

Hidradenitis suppurativa; Squamous cell carcinoma; Human papillomavirus; Polymerase chain reaction; MICROARRAY PRIMER EXTENSION; HUMAN-PAPILLOMAVIRUS; MARJOLINS ULCER; MULTIPLEX PCR; PREVALENCE; MANAGEMENT; HYPERCALCEMIA; ASSOCIATION; ETANERCEPT; PATIENT;

D O I：

10.1159/000269836

中图分类号：

R75 [皮肤病学与性病学];

学科分类号：

100206 ;

摘要：

Background: To the best of our knowledge, only 52 cases of squamous cell carcinoma (SCC) complicating hidradenitis suppurativa (HS) have been reported since 1958. We describe 13 new cases. Methods: We propose a clinical and histological analysis of our cases. We include these results in a review of previously reported cases to analyze a total of 65 patients. In our series of 13 cases, we also investigate the presence of human papillomavirus (HPV) in tumor samples, by polymerase chain reaction (PCR) on paraffin-embedded material. Results: Malignant transformation affects mainly men with a long-term history of genitoanal HS. Although our cases were 7 well-differentiated carcinomas and 6 verrucous carcinomas, lymphatic and visceral metastasis occurred in 2 and 3 cases, respectively. With PCR, we demonstrated presence of HPV in genitoanal tumoral lesions, principally HPV-16. Conclusion: SCC complicating HS evolves poorly, despite a good histological prognosis. Our results sustain the implication of HPV in the malignant transformation of HS. Copyright (C) 2009 S. Karger AG, Basel

引用

页码：147 / 153

页数：7

共 59 条

[1]

ALEXANDER SJ, 1979, CANCER-AM CANCER SOC, V43, P745, DOI 10.1002/1097-0142(197902)43:2<745::AID-CNCR2820430251>3.0.CO

[2]

2-D

[3] Hidradenitis suppurativa and squamous cell carcinoma [J].