Disruption of transepithelial resistance by enterotoxigenic Escherichia coli

被引：38

作者：

Johnson, Amber M. ^{[2
,3
]}

Kaushik, Radhey S. ^{[2
,3
]}

Hardwidge, Philip R. ^{[1
]}

机构：

[1] Univ Kansas, Med Ctr, Dept Microbiol Mol Genet & Immunol, Kansas City, KS 66160 USA

[2] S Dakota State Univ, Dept Vet Sci, Brookings, SD 57007 USA

[3] S Dakota State Univ, Dept Biol & Microbiol, Brookings, SD 57007 USA

来源：

VETERINARY MICROBIOLOGY | 2010年 / 141卷 / 1-2期

关键词：

Bacterial pathogenesis; Enterotoxigenic Escherichia call; Tight junction; Transepithelial resistance; JUNCTION BARRIER FUNCTION; HEAT-LABILE ENTEROTOXIN; TIGHT-JUNCTION; IN-VITRO; STRAIN; CELLS; PATHOGENESIS; DYSFUNCTION; ADHERENCE; MUTANT;

D O I：

10.1016/j.vetmic.2009.08.020

中图分类号：

Q93 [微生物学];

学科分类号：

071005 ; 100705 ;

摘要：

Transepithelial resistance and tight junction protein localization in porcine intestinal epithelial cells were evaluated as a function of infection with porcine enterotoxigenic Escherichia coli isolates differing in adhesin and enterotoxin profiles. Robust heat-labile enterotoxin-independent reduction of host transepithelial resistance was observed in the absence of tight junction protein mislocalization. (C) 2009 Elsevier B.V. All rights reserved.

引用

页码：115 / 119

页数：5

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