Dorsal periaqueductal gray matter-evoked panic-like behaviors are markedly inhibited by a low peripheral dose of thyrotropin releasing hormone

被引:4
作者
Siqueira, Carla Coelho [1 ]
Rossoni, Renzo Roldi [1 ]
Schenberg, Luiz Carlos [1 ]
机构
[1] Univ Fed Espirito Santo, Dept Ciencias Fisiol, CCS, BR-29043125 Vitoria, ES, Brazil
关键词
TRH; Thyroid; PAG; Flight; Freezing; Anxiety; Elevated plus-maze; Rat; VENTRAL MEDULLARY NEURONS; FOS-LIKE IMMUNOREACTIVITY; CAUDAL RAPHE NUCLEI; DEFENSIVE BEHAVIORS; THYROID-HORMONE; LOCUS-CERULEUS; GENE-EXPRESSION; SUBSTANCE-P; RAT; TRH;
D O I
10.1016/j.psyneuen.2009.06.021
中图分类号
R5 [内科学];
学科分类号
1002 ; 100201 ;
摘要
Stimulation of the dorsal periaqueductal gray matter (DPAG) produces defensive behaviors which are reminiscent of panic attacks. Recent evidence from our laboratory showed that DPAG-evoked defensive behaviors are markedly attenuated in short-term methimazole-induced hypothyroidism. It is not clear, however, whether these effects were due to an increase in thyrotropin releasing hormone (TRH), a decrease in thyroid hormones or to the overall effects of hypothyroidism. Accordingly, here we examined whether the peripheral injection of TRH has any effect either on the panic-like behaviors induced by electrical stimulation of DPAG or anxiety-like behaviors of rats exposed to the elevated plus-maze (EPM). Rats whose stimulation of DPAG produced flight responses (galloping or jumping) with intensities below 60 LA were injected with 1 mu g/kg TRH (i.p.) and stimulated 10 min after that. The day after, rats were treated with saline and subjected to the same stimulation procedure. Threshold curves were fitted through the logistic model and compared by likelihood-ratio chi(2) tests. TRH and saline effects on EPM performance were appraised in separate groups. Compared to saline-sessions, TRH-injected rats presented thresholds significantly higher for immobility (40%), trotting (33%), galloping (34%), jumping (39%) and exophthalmus (43%). In contrast, TRH had no effects on EPM arm exploration. TRH selective inhibition of DPAG-evoked defensive behaviors adds new evidence that panic attacks may be attenuated by increased levels of this hormone in hypothyroidism. (C) 2009 Elsevier Ltd. All rights reserved.
引用
收藏
页码:262 / 271
页数:10
相关论文
共 71 条
  • [1] ARNOLD R, 1991, BIOMED BIOCHIM ACTA, V50, P1217
  • [2] IDENTIFICATION OF MIDBRAIN NEURONS MEDIATING DEFENSIVE BEHAVIOR IN THE RAT BY MICROINJECTIONS OF EXCITATORY AMINO-ACIDS
    BANDLER, R
    DEPAULIS, A
    VERGNES, M
    [J]. BEHAVIOURAL BRAIN RESEARCH, 1985, 15 (02) : 107 - 119
  • [3] Cholecystokinin-2 receptors modulate freezing and escape behaviors evoked by the electrical stimulation of the rat dorsolateral periaqueductal gray
    Bertoglio, Leandro Jose
    de Bortoli, Valquiria Camin
    Zangrossi, Helio, Jr.
    [J]. BRAIN RESEARCH, 2007, 1156 : 133 - 138
  • [4] Organization of electrically and chemically evoked defensive behaviors within the deeper collicular layers as compared to the periaqueductal gray matter of the rat
    Bittencourt, AS
    Nakamura-Palacios, EM
    Mauad, H
    Tufik, S
    Schenberg, LC
    [J]. NEUROSCIENCE, 2005, 133 (04) : 873 - 892
  • [5] Organization of single components of defensive behaviors within distinct columns of periaqueductal gray matter of the rat:: Role of N-methyl-D-aspartic acid glutamate receptors
    Bittencourt, AS
    Carobrez, AP
    Zamprogno, LP
    Tufik, S
    Schenberg, LC
    [J]. NEUROSCIENCE, 2004, 125 (01) : 71 - 89
  • [6] BLANCHARD DC, 1981, PHYSIOL PSYCHOL, V9, P157
  • [7] The central nervous system control of micturition in cats and humans
    Blok, BFM
    Holstege, G
    [J]. BEHAVIOURAL BRAIN RESEARCH, 1998, 92 (02) : 119 - 125
  • [8] Fos-like immunoreactivity in the periaqueductal gray of rats exposed to a natural predator
    Canteras, NS
    Goto, M
    [J]. NEUROREPORT, 1999, 10 (02) : 413 - 418
  • [9] Misinterpretation of body sensations in panic disorder
    Clark, DM
    Salkovskis, PM
    Ost, LG
    Breitholtz, E
    Koehler, KA
    Westling, BE
    Jeavons, A
    Gelder, M
    [J]. JOURNAL OF CONSULTING AND CLINICAL PSYCHOLOGY, 1997, 65 (02) : 203 - 213
  • [10] COLLETT D, 2003, C&H TEXT STAT SCI, P1