Aging Mice Show a Decreasing Correlation of Gene Expression within Genetic Modules

被引:129
作者
Southworth, Lucinda K. [1 ]
Owen, Art B. [1 ]
Kim, Stuart K. [1 ]
机构
[1] Stanford Univ, Stanford, CA 94305 USA
来源
PLOS GENETICS | 2009年 / 5卷 / 12期
基金
美国国家卫生研究院; 美国国家科学基金会;
关键词
NF-KAPPA-B; GENOME BROWSER DATABASE; MAPPING DATA; COEXPRESSION; PROTEIN; NETWORKS; TRANSCRIPTOME; INTERACTOME; ACTIVATION; DISCOVERY;
D O I
10.1371/journal.pgen.1000776
中图分类号
Q3 [遗传学];
学科分类号
071007 ; 090102 ;
摘要
In this work we present a method for the differential analysis of gene co-expression networks and apply this method to look for large-scale transcriptional changes in aging. We derived synonymous gene co-expression networks from AGEMAP expression data for 16-month-old and 24-month-old mice. We identified a number of functional gene groups that change co-expression with age. Among these changing groups we found a trend towards declining correlation with age. In particular, we identified a modular (as opposed to uniform) decline in general correlation with age. We identified potential transcriptional mechanisms that may aid in modular correlation decline. We found that computationally identified targets of the NF-KB transcription factor decrease expression correlation with age. Finally, we found that genes that are prone to declining co-expression tend to be co-located on the chromosome. Our results conclude that there is a modular decline in co-expression with age in mice. They also indicate that factors relating to both chromosome domains and specific transcription factors may contribute to the decline.
引用
收藏
页数:13
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