Sleep Apnea Research in Animals Past, Present, and Future

被引：57

作者：

Chopra, Swati ^{[1
]}

Polotsky, Vsevolod Y. ^{[1
]}

Jun, Jonathan C. ^{[1
]}

机构：

[1] Johns Hopkins Univ, Sch Med, Dept Med, Div Pulm & Crit Care Med, 5501 Hopkins Bayview Circle,Room 4A30A, Baltimore, MD 21224 USA

来源：

AMERICAN JOURNAL OF RESPIRATORY CELL AND MOLECULAR BIOLOGY | 2016年 / 54卷 / 03期

关键词：

sleep apnea; animal; intermittent hypoxia; fragmentation; CHRONIC INTERMITTENT HYPOXIA; BLOOD-PRESSURE; OPTOGENETIC CONTROL; AIRWAY-OBSTRUCTION; MOUSE MODEL; RAT MODEL; FRAGMENTATION; RESPONSES; INFLAMMATION; AROUSAL;

D O I：

10.1165/rcmb.2015-0218TR

中图分类号：

Q5 [生物化学]; Q7 [分子生物学];

学科分类号：

071010 ; 081704 ;

摘要：

Obstructive sleep apnea (OSA) is a common disorder that describes recurrent collapse of theupper airway during sleep. Animal models have been pivotal to the understanding of OSA pathogenesis, consequences, and treatment. In this review, we highlight the history of OSA research in animals and include the discovery of animals with spontaneous OSA, the induction of OSA in animals, and the emulation of OSA using exposures to intermittent hypoxia and sleep fragmentation.

引用

页码：299 / 305

页数：7

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