Synthesis and ANTI-HCMV activity of novel 2′,3′,4′-trimethyl branched carbocyclic nucleosides

被引：4

作者：

Kim, A ^{[1
]}

Hong, JH ^{[1
]}

机构：

[1] Chosun Univ, Coll Pharm, Kwangju 501759, South Korea

来源：

NUCLEOSIDES NUCLEOTIDES & NUCLEIC ACIDS | 2005年 / 24卷 / 01期

关键词：

antiviral agents; triply branched carbocyclic nucleosides; 3,3]-sigmatropic rearrangement;

D O I：

10.1081/NCN-200046786

中图分类号：

Q5 [生物化学]; Q7 [分子生物学];

学科分类号：

071010 ; 081704 ;

摘要：

This article reports the synthesis of novel 2',3',4'-trimethyl branched carbocyclic nucleosides. The introduction Of a methyl group in the 2' and 3'-position was accomplished by sequential Horner Wadsworth-Emmons reaction and isopropenyl magnesiumbromide addition, respectively. The construction of the 4'-quaternary carbon needed was carried out using a [3,3]-sigmatropic rearrangement. Bis-vinyls were successfully cyclized using a Grubbs catalyst II. The natural bases (adenine, cytosine) were efficiently coupled with the use of a Pd(0) catalyst.

引用

页码：63 / 72

页数：10

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