Lifelong protection against hepatitis B: the role of vaccine immunogenicity in immune memory

被引：153
作者：
Banatvala, J
Van Damme, P
Oehen, S
机构：
[1] John Radcliffe Hosp, Dept Microbiol, Oxford OX3 9DU, England
[2] Univ Antwerp, Dept Epidemiol, Ctr Evaluat Vaccinat, B-2020 Antwerp, Belgium
[3] Univ Zurich Hosp, Inst Expt Immunol, CH-8091 Zurich, Switzerland
来源：
VACCINE | 2000年 / 19卷 / 7-8期
关键词：
hepatitis B; vaccine immunogenicity; immune memory;
D O I：
10.1016/S0264-410X(00)00224-3
中图分类号：
R392 [医学免疫学]; Q939.91 [免疫学];
学科分类号：
100102 ;
摘要：
Long-term protection against hepatitis B (HB) disease is dependent on persistence of a strong immune memory. This paper presents and discusses new knowledge that allows a better understanding of the mechanisms of long-term protection following hepatitis B vaccination. Studies have revealed links between specific lymphoproliferation, the in vivo humoral response and immune memory. The strength of immune memory and of a subsequent secondary immune response can therefore be predicted by the antibody response following primary vaccination. Vaccine antigen dose and structure have been identified as important influences in the primary antibody response and development of immune memory. The data and considerations presented support the use of highly immunogenic HE vaccines in order to provide long-lasting protection against HE disease. (C) 2000 Elsevier Science Ltd. All rights reserved.
引用
收藏
页码：877 / 885
页数：9
相关论文
共 59 条
[1]   REGULATION OF IGG ANTIBODY-TITERS BY THE AMOUNT OF PERSISTING IMMUNE-COMPLEXED ANTIGEN [J].
BACHMANN, MF ;
KUNDIG, TM ;
HENGARTNER, H ;
ZINKERNAGEL, RM .
EUROPEAN JOURNAL OF IMMUNOLOGY, 1994, 24 (10) :2567-2570
[2]   The role of B cells in acute and chronic infections [J].
Bachmann, MF ;
Kopf, M .
CURRENT OPINION IN IMMUNOLOGY, 1999, 11 (03) :332-339
[3]  
BACHMANN MF, 1994, J IMMUNOL, V153, P3386
[4]   THE INFLUENCE OF ANTIGEN ORGANIZATION ON B-CELL RESPONSIVENESS [J].
BACHMANN, MF ;
ROHRER, UH ;
KUNDIG, TM ;
BURKI, K ;
HENGARTNER, H ;
ZINKERNAGEL, RM .
SCIENCE, 1993, 262 (5138) :1448-1451
[5]   Neutralizing antiviral B cell responses [J].
Bachmann, MF ;
Zinkernagel, RM .
ANNUAL REVIEW OF IMMUNOLOGY, 1997, 15 :235-270
[6]   Induction of long-lived germinal centers associated with persisting antigen after viral infection [J].
Bachmann, MF ;
Odermatt, B ;
Hengartner, H ;
Zinkernagel, RM .
JOURNAL OF EXPERIMENTAL MEDICINE, 1996, 183 (05) :2259-2269
[7]   Protection against immunopathological consequences of a viral infection by activated but not resting cytotoxic T cells: T cell memory without ''memory T cells''? [J].
Bachmann, MF ;
Kundig, TM ;
Hengartner, H ;
Zinkernagel, RM .
PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA, 1997, 94 (02) :640-645
[8]   The influence of virus structure on antibody responses and virus serotype formation [J].
Bachmann, MF ;
Zinkernagel, RM .
IMMUNOLOGY TODAY, 1996, 17 (12) :553-558
[9]  
Banatvala J, 2000, LANCET, V355, P561, DOI 10.1016/S0140-6736(99)07239-6
[10]  
BEASLEY RP, 1988, CANCER, V61, P1942, DOI 10.1002/1097-0142(19880515)61:10<1942::AID-CNCR2820611003>3.0.CO
123456